Introduction：Basic information about CAS 1321514-06-0|AZD-4635, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AZD-4635 |
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| CAS Number | 1321514-06-0 | Molecular Weight | 315.73300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C15H11ClFN5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine |
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| Synonym | More Synonyms |
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AZD-4635 BiologicalActivity
| Description | AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adenosine ReceptorResearch Areas >>Cancer |
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| Target | Ki: 1.7 nM (A2AR) |
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| References | [1]. Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580. |
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Chemical & Physical Properties
| Molecular Formula | C15H11ClFN5 |
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| Molecular Weight | 315.73300 |
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| Exact Mass | 315.06900 |
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| PSA | 77.58000 |
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| LogP | 3.86490 |
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| InChIKey | NCWQLHHDGDXIJN-UHFFFAOYSA-N |
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| SMILES | Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(Cl)n1 |
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| Storage condition | -20℃ |
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Synonyms
| AZD-4635 |
| AZD4635 |
| 6-(2-Chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine |
