CAS 1316755-16-4|EMA401

Introduction：Basic information about CAS 1316755-16-4|EMA401, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. EMA401 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	EMA401
CAS Number	1316755-16-4	Molecular Weight	507.576
Density	1.3±0.1 g/cm3	Boiling Point	745.3±60.0 °C at 760 mmHg
Molecular Formula	C₃₂H₂₉NO₅	Melting Point	/
MSDS	/	Flash Point	404.5±32.9 °C

Names

Name	EMA401
Synonym	More Synonyms

EMA401 BiologicalActivity

Description	Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorResearch Areas >>Neurological Disease
References	[1]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47. [2]. Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38. [3]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

Description

Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorResearch Areas >>Neurological Disease

References

[1]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

[2]. Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.

[3]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	745.3±60.0 °C at 760 mmHg
Molecular Formula	C₃₂H₂₉NO₅
Molecular Weight	507.576
Flash Point	404.5±32.9 °C
Exact Mass	507.204559
LogP	5.98
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.631
InChIKey	GHBCIXGRCZIPNQ-MHZLTWQESA-N
SMILES	COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2

Synonyms

3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)-

(3S)-5-(Benzyloxy)-2-(diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

EMA401

(3S)-5-(benzyloxy)-2-(diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

P0FN522VTO

olodanrigan

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