CAS 1340593-59-0|VT-1161

Introduction：Basic information about CAS 1340593-59-0|VT-1161, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. VT-1161 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	VT-1161
CAS Number	1340593-59-0	Molecular Weight	527.394
Density	1.5±0.1 g/cm3	Boiling Point	609.2±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₁₆F₇N₅O₂	Melting Point	/
MSDS	/	Flash Point	322.3±34.3 °C

Names

Name	oteseconazole
Synonym	More Synonyms

VT-1161 BiologicalActivity

Description	Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Signaling Pathways >>Anti-infection >>Fungal
References	[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.

Description

Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51[1][2].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Signaling Pathways >>Anti-infection >>Fungal

References

[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.

[2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	609.2±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₁₆F₇N₅O₂
Molecular Weight	527.394
Flash Point	322.3±34.3 °C
Exact Mass	527.119202
LogP	5.70
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.570
InChIKey	IDUYJRXRDSPPRC-NRFANRHFSA-N
SMILES	OC(Cn1cnnn1)(c1ccc(F)cc1F)C(F)(F)c1ccc(-c2ccc(OCC(F)(F)F)cc2)cn1

Synonyms

VHH774W97N

2-Pyridineethanol, α-(2,4-difluorophenyl)-β,β-difluoro-α-(1H-tetrazol-1-ylmethyl)-5-[4-(2,2,2-trifluoroethoxy)phenyl]-, (αR)-

oteseconazole

(2R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]-2-pyridinyl}-2-propanol

10138

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