CAS 1325559-33-8|NifluMic acid-13C6
| Common Name | NifluMic acid-13C6 | ||
|---|---|---|---|
| CAS Number | 1325559-33-8 | Molecular Weight | 288.174 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C713C6H9F3N2O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | NifluMic acid-13C6 |
|---|---|
| Synonym | More Synonyms |
NifluMic acid-13C6 BiologicalActivity
| Description | Niflumic acid-13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Chloride ChannelResearch Areas >>Inflammation/Immunology |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Criddle, D.N., et al., Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol, 1997. 120(5): p. 813-8. [3]. Jabeen, T., et al., Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr, 2005. 61(Pt 12): p. 1579-86. [4]. Picollo, A., et al., Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol, 2007. 216(2-3): p. 73-82. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C713C6H9F3N2O2 |
| Molecular Weight | 288.174 |
| Exact Mass | 288.081726 |
| Index of Refraction | 1.589 |
| InChIKey | JZFPYUNJRRFVQU-IKCRXMKJSA-N |
| SMILES | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22-36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
Synonyms
| 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl-1,2,3,4,5,6-13C6]amino]- |
| MFCD19704813 |
| Niflumic acid-(phenyl-13C6) |
| 2-(3-Trifluoromethylphenyl-13C6-amino)nicotinic acid |
| 2-{[3-(Trifluoromethyl)(13C6)phenyl]amino}nicotinic acid |
