Introduction：Basic information about CAS 138168-48-6|Tyroserleutide (YSL), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyroserleutide (YSL) |
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| CAS Number | 138168-48-6 | Molecular Weight | 381.423 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 763.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C18H27N3O6 | Melting Point | / |
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| MSDS | / | Flash Point | 415.7±32.9 °C |
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Names
| Name | Tyroserleutide |
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| Synonym | More Synonyms |
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Tyroserleutide (YSL) BiologicalActivity
| Description | Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | Antitumor tripeptide[1][2] |
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| In Vitro | Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1]. Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2]. Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2]. Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2]. |
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| In Vivo | Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1]. Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1] Dosage: 10, 20, 40, and 80 μg/kg Administration: Injection (i.p.) one time every day until mice were dead. Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively. |
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| References | [1]. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95. [2]. Liang P, et al. pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy. Adv Healthc Mater. 2019 Aug;8(15):e1900306. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 763.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C18H27N3O6 |
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| Molecular Weight | 381.423 |
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| Flash Point | 415.7±32.9 °C |
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| Exact Mass | 381.189972 |
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| LogP | 0.89 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.577 |
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| InChIKey | MQGGXGKQSVEQHR-KKUMJFAQSA-N |
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| SMILES | CC(C)CC(NC(=O)C(CO)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O |
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Synonyms
| L-Tyrosyl-L-seryl-L-leucine |
| L-Leucine, L-tyrosyl-L-seryl- |
