CAS 1383658-09-0|m-PEG10-amine

Introduction：Basic information about CAS 1383658-09-0|m-PEG10-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. m-PEG10-amine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	m-PEG10-amine
CAS Number	1383658-09-0	Molecular Weight	471.583
Density	1.1±0.1 g/cm3	Boiling Point	518.9±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₄₅NO₁₀	Melting Point	/
MSDS	/	Flash Point	254.4±22.4 °C

Names

Name	m-PEG10-amine
Synonym	More Synonyms

m-PEG10-amine BiologicalActivity

Description	m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Jennifer Riggs-Sauthier, et al. Polymer-semaxanib moiety conjugates. US20140011855A1.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	518.9±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₄₅NO₁₀
Molecular Weight	471.583
Flash Point	254.4±22.4 °C
Exact Mass	471.304352
LogP	-3.88
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.456
InChIKey	JVILNPVFPORAFH-UHFFFAOYSA-N
SMILES	COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Storage condition	2-8°C

Synonyms

2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-amine

MFCD27977522

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