CAS 166527-00-0|7-Desmethyl-3-hydroxyagomelatine
Introduction：Basic information about CAS 166527-00-0|7-Desmethyl-3-hydroxyagomelatine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7-Desmethyl-3-hydroxyagomelatine | ||
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| CAS Number | 166527-00-0 | Molecular Weight | 245.2738 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H15NO3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 7-DesMethyl-3-hydroxyagoMelatine |
|---|
7-Desmethyl-3-hydroxyagomelatine BiologicalActivity
| Description | 7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine[1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Melatonin ReceptorSignaling Pathways >>GPCR/G Protein >>Melatonin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | MT1 MT2 5-HT2C Receptor |
| References | [1]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6. [2]. Kennedy SH, et al. Agomelatine and its therapeutic potential in the depressed patient. Neuropsychiatr Dis Treat. 2007 Aug;3(4):423-8. |
Chemical & Physical Properties
| Molecular Formula | C14H15NO3 |
|---|---|
| Molecular Weight | 245.2738 |
| InChIKey | FMUHSDLSKQLNNB-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCc1cc(O)cc2ccc(O)cc12 |
