Introduction：Basic information about CAS 1314378-12-5|Bis-PEG4-PFP ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bis-PEG4-PFP ester |
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| CAS Number | 1314378-12-5 | Molecular Weight | 626.395 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 570.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H20F10O8 | Melting Point | / |
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| MSDS | / | Flash Point | 287.7±25.0 °C |
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Names
| Name | Bis-PEG4-PFP ester |
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| Synonym | More Synonyms |
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Bis-PEG4-PFP ester BiologicalActivity
| Description | Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Alkyl/ether |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 570.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H20F10O8 |
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| Molecular Weight | 626.395 |
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| Flash Point | 287.7±25.0 °C |
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| Exact Mass | 626.099854 |
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| LogP | 3.92 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.463 |
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| InChIKey | RCCGHSXHOCFIBV-UHFFFAOYSA-N |
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| SMILES | O=C(CCOCCOCCOCCOCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F)Oc1c(F)c(F)c(F)c(F)c1F |
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Synonyms
| Bis(pentafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate |
| MFCD21363293 |
| 4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester |
