Introduction：Basic information about CAS 136826-50-1|1-Dehydro-[10]-gingerdione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Dehydro-[10]-gingerdione |
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| CAS Number | 136826-50-1 | Molecular Weight | 346.461 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 495.2±40.0 °C at 760 mmHg |
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| Molecular Formula | C21H30O4 | Melting Point | / |
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| MSDS | / | Flash Point | 166.3±20.8 °C |
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Names
| Name | 1-Dehydro-10-gingerdione |
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| Synonym | More Synonyms |
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1-Dehydro-[10]-gingerdione BiologicalActivity
| Description | 1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1]. |
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| Related Catalog | Signaling Pathways >>NF-κB >>IKKResearch Areas >>Inflammation/Immunology |
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| References | [1]. Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 495.2±40.0 °C at 760 mmHg |
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| Molecular Formula | C21H30O4 |
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| Molecular Weight | 346.461 |
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| Flash Point | 166.3±20.8 °C |
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| Exact Mass | 346.214417 |
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| LogP | 5.51 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.531 |
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Synonyms
| 1-Tetradecene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-, (1E)- |
| (1E)-1-(4-Hydroxy-3-methoxyphenyl)-1-tetradecene-3,5-dione |
