Introduction：Basic information about CAS 1398044-50-2|Thiol-PEG2-t-butyl ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thiol-PEG2-t-butyl ester |
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| CAS Number | 1398044-50-2 | Molecular Weight | 250.355 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 330.6±27.0 °C at 760 mmHg |
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| Molecular Formula | C11H22O4S | Melting Point | / |
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| MSDS | / | Flash Point | 200.0±11.6 °C |
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Names
| Name | Thio-PEG2-t-butyl ester |
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| Synonym | More Synonyms |
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Thiol-PEG2-t-butyl ester BiologicalActivity
| Description | Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 330.6±27.0 °C at 760 mmHg |
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| Molecular Formula | C11H22O4S |
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| Molecular Weight | 250.355 |
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| Flash Point | 200.0±11.6 °C |
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| Exact Mass | 250.123886 |
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| LogP | 1.75 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.462 |
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| InChIKey | WUDGYPDPSZWMNE-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)CCOCCOCCS |
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Synonyms
| Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]-, 1,1-dimethylethyl ester |
| MFCD22574781 |
| 2-Methyl-2-propanyl 3-[2-(2-sulfanylethoxy)ethoxy]propanoate |
