Introduction：Basic information about CAS 187269-40-5|Bimosiamose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bimosiamose |
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| CAS Number | 187269-40-5 | Molecular Weight | 862.911 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 1051.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C46H54O16 | Melting Point | / |
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| MSDS | / | Flash Point | 309.7±27.8 °C |
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Names
| Name | bimosiamose |
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| Synonym | More Synonyms |
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Bimosiamose BiologicalActivity
| Description | Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1] |
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| In Vitro | Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1]. |
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| In Vivo | Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1]. |
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| References | [1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 1051.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C46H54O16 |
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| Molecular Weight | 862.911 |
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| Flash Point | 309.7±27.8 °C |
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| Exact Mass | 862.341187 |
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| LogP | 3.04 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.649 |
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| InChIKey | RYWCQJDEHXJHRI-XJMXIVSISA-N |
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| SMILES | O=C(O)Cc1cccc(-c2cc(CCCCCCc3ccc(OC4OC(CO)C(O)C(O)C4O)c(-c4cccc(CC(=O)O)c4)c3)ccc2OC2OC(CO)C(O)C(O)C2O)c1 |
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Safety Information
Synonyms
| bimosiamose |
| [1,1'-Biphenyl]-3-acetic acid, 3',3''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)- |
| 97B5KCW80W |
| 2,2'-{1,6-Hexanediylbis[6'-(α-D-mannopyranosyloxy)-3',3-biphenyldiyl]}diacetic acid |
| 8074 |
