Introduction：Basic information about (-)-Camphanic acid chloride CAS 39637-74-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(-)-Camphanic acid chloride Basic information
| Product Name: | (-)-Camphanic acid chloride |
| Synonyms: | (-)-CAMPHANIC ACID CHLORIDE;(1S)-(-)-Camphanicacidchloride;3-oxa-2-oxobornane-4-carbonyl chloride;(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chlorid;(1S)-(-)-Camphanicchloride,95%;(1S,4R)-(-)-Camphanic chloride;(1S)-(-)-Camphanic chloride, 98% (99% EE);(-)-CAMPHANIC ACID CHLORIDE 98% |
| CAS: | 39637-74-6 |
| MF: | C10H13ClO3 |
| MW: | 216.66 |
| EINECS: | 254-552-4 |
| Product Categories: | Chiral Reagents;Chiral Compound;FINE Chemical & INTERMEDIATES;Chemical intermediate for Efavirenz;Bicyclic Monoterpenes;Biochemistry;for Resolution of Alcohols & Thiols;Optical Resolution;Synthetic Organic Chemistry;Terpenes |
| Mol File: | 39637-74-6.mol |
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(-)-Camphanic acid chloride Chemical Properties
| Melting point | 71-73 °C(lit.) |
| alpha | -18 º (c=2, CCl4) |
| Boiling point | 310.92°C (rough estimate) |
| density | 1.2072 (rough estimate) |
| refractive index | 1.5390 (estimate) |
| storage temp. | 2-8°C |
| solubility | soluble in Dichloromethane, Ether, Ethyl Acetate, Methanol |
| form | Powder |
| color | Yellow to orange-brown |
| Optical Rotation | [α]23/D 18°, c = 2 in carbon tetrachloride |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 3590860 |
| InChI | 1S/C10H13ClO3/c1-8(2)9(3)4-5-10(8,6(11)12)14-7(9)13/h4-5H2,1-3H3/t9-,10+/m0/s1 |
| InChIKey | PAXWODJTHKJQDZ-RGURZIINSA-N |
| SMILES | CC1(C)[C@@]2(C)CC[C@@]1(OC2=O)C(Cl)=O |
| CAS DataBase Reference | 39637-74-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | C,Xi |
| Risk Statements | 34-29 |
| Safety Statements | 26-36/37/39-45-8-27 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| F | 10-21 |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29322090 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
(-)-Camphanic acid chloride Usage And Synthesis
| Chemical Properties | Off-White Powder |
| Uses | An optically active resolving agent |
| Uses | (1S)-(-)-Camphanic chloride is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines. |
| Uses | (1S)-(-)-Camphanic chloride may be used in esterification of enantiomers in volatiles releasedf from wheat, in order to determine the proportion of enantiomers and also in quantifying the esters. |
| General Description | (1S)-(-)-Camphanic chloride is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride. |
| Purification Methods | It is soluble in toluene (50g/100mL at 0o) and crystallises from pet ether (b 40-60o). It sublimes at 70o/5mm, Store it dry at 0o, max (CCl4) 1805s and 1780m cm-1. Armarego et al. J Chem Soc, Perkin Trans I 2229 1976, Gerlach Helv Chim Acta 51 1587 1968, Gerlach Helv Chim Acta 68 1815 1985, Beilstein 18/8 V 101.] |
(-)-Camphanic acid chloride Preparation Products And Raw materials
| Raw materials | D-(+)-Camphoric acid |
