2-Aminobenzenesulfonamide CAS 3306-62-5
Introduction：Basic information about 2-Aminobenzenesulfonamide CAS 3306-62-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Aminobenzenesulfonamide Basic information
| Product Name: | 2-Aminobenzenesulfonamide |
| Synonyms: | 2-amino-benzenesulfonamid;Benzenesulfonamide, 2-amino- (9CI);2-Aminobenzenesulfonamide ,98%;2-Aminobenzenesulfamide;2-Sulphamoylaniline;2-AMinobenzenesulfonaMide, 98% 5GR;2-Aminobenzenesulfonamde;2-Amino-benzenesulfomide |
| CAS: | 3306-62-5 |
| MF: | C6H8N2O2S |
| MW: | 172.2 |
| EINECS: | 221-988-1 |
| Product Categories: | Inhibitors;Sulphur Derivatives;Benzene derivates;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;SULFONAMIDE;Intermediates of Dyes and Pigments |
| Mol File: | 3306-62-5.mol |
2-Aminobenzenesulfonamide Chemical Properties
| Melting point | 155-157 °C(lit.) |
| Boiling point | 392.7±44.0 °C(Predicted) |
| density | 1.3250 (rough estimate) |
| refractive index | 1.6490 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 10.29±0.60(Predicted) |
| color | Off-White to Beige |
| Water Solubility | 6.655g/L(24 ºC) |
| InChI | InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) |
| InChIKey | YAZSBRQTAHVVGE-UHFFFAOYSA-N |
| SMILES | C1(S(N)(=O)=O)=CC=CC=C1N |
| CAS DataBase Reference | 3306-62-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 36/37/39-26-22-36 |
| WGK Germany | 3 |
| RTECS | DA9449000 |
| Hazard Note | Irritant |
| HS Code | 29350090 |
| Storage Class | 11 - Combustible Solids |
| Chemical Properties | white to pale cream crystalline powder or crystals |
| Uses | Diuretic;Inhibitor of carbonic anhydrase B |
| Definition | ChEBI: 2-aminobenzenesulfonamide is a sulfonamide and a member of benzenes. |
| Synthesis | 5455-59-4 3306-62-5 General procedure for the synthesis of o-aminobenzenesulfonamide from 2-nitrobenzenesulfonamide: 2-nitrobenzenesulfonamide (80.0 g, 0.58 mol) was dissolved in methanol in the presence of a Pd/C catalyst (10.0 g, 13% w/w) to prepare a solution with a mass concentration of 10%. The hydrogenation reaction was carried out at 50 psi hydrogen pressure and 60°C and the reaction was continued overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give 60 g of off-white solid o-aminobenzenesulfonamide in 95% yield. |
| IC 50 | CA Ⅸ |
| Solubility in organics | 2-Aminobenzenesulfonamide is freely soluble in water, glacial acetic acid, ethyl alcohol, acetone, and methanol; insoluble in benzene. |
| References | [1] Patent: CN104761514, 2016, B. Location in patent: Paragraph 0028-0030 [2] Tetrahedron Letters, 2001, vol. 42, # 33, p. 5601 - 5603 [3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2455 - 2478 [4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5647 - 5647 [5] Bihang till Svenska Vet.-Akad. Handlingar, vol. 27, p. II, No. 1, S. 4 |
2-Aminobenzenesulfonamide Preparation Products And Raw materials
| Raw materials | Ethanol-->Palladium-->Hydrazinium hydroxide solution-->2-Nitrobenzenesulfonamide-->2-benzyl-1,1-dioxo-4H-1$l^{6},2,4-benzothiadiazin-3-one-->Methanol-->Hydrogen-->Activated carbon |
| Preparation Products | N,N'-DIACETYLSULFANILAMIDE-->2H-1,2,4-Benzothiadiazine 1,1-dioxide-->Benzenesulfonamide, 2-hydrazino- (9CI)-->2-Amino-5-bromobenzenesulfonamide-->2-IODOBENZENE-1-SULFONAMIDE, 95%+ |
