Introduction：Basic information about 2'-O-Methyluridine CAS 2140-76-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2'-O-Methyluridine Basic information
| Product Name: | 2'-O-Methyluridine |
| Synonyms: | 2'-O-METHYLURIDINE (CHIRAL);2''-O-METHYLURIDINE CRYSTALLINE;1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone;1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione;1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione;1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHOXYOXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE;2'-O-Methyluridine 98+%;2'-O-Methyluridine, 98.0 % |
| CAS: | 2140-76-3 |
| MF: | C10H14N2O6 |
| MW: | 258.23 |
| EINECS: | 2017-001-1 |
| Product Categories: | pyrimidine;Heterocycle-Pyrimidine series;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Pharmaceutical;2140-76-3;Nucleosides;Modified（deoxy）nucleoside;Nucleosides-2'-OMe Nucleosides |
| Mol File: | 2140-76-3.mol |
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2'-O-Methyluridine Chemical Properties
| Melting point | 154-156°C |
| density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.39±0.10(Predicted) |
| form | Powder |
| color | White to Off-white |
| PH | ～9.3 |
| λmax | 261nm(MeOH)(lit.) |
| InChI | InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1 |
| InChIKey | SXUXMRMBWZCMEN-ZOQUXTDFSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O |
| CAS DataBase Reference | 2140-76-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 24/25 |
| WGK Germany | WGK 3 |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
2'-O-Methyluridine Usage And Synthesis
| Description | 2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. |
| Chemical Properties | White Solid |
| Uses | Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication. |
| Uses | Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication. |
| Definition | ChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring. |
| Source | 2'-O-Methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea, Bacteria, and Eukaryota[1]. |
| References | [1] Agota Au?ynait?. “Identification of a 2’-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries.” Molecules 23 11 (2018). |
2'-O-Methyluridine Preparation Products And Raw materials
| Raw materials | Uridine, 2'-O-methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- |
| Preparation Products | 3-METHYL URIDINE |
