2'-O-MOE-5MeU-3'-phosphoramidite CAS 163878-63-5

Introduction：Basic information about 2'-O-MOE-5MeU-3'-phosphoramidite CAS 163878-63-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2'-O-MOE-5MeU-3'-phosphoramidite Basic information

• Product Name: 2'-O-MOE-5MeU-3'-phosphoramidite
• Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-(2-METHOXYETHOXY)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE;2-O-MOE-5-Methyl-Uridine Phosphoramidite;5'-O-DMT-2'-O-methyl-5-methyluridine;5-Me-DMT-2'-O-Me-Ur;5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine;2'-O-MOE-5MeU-3'-phosphoramidite;5'-O-DMTR-2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE-3'-CED-PHOSPHORAMIDITE
• CAS: 163878-63-5
• MF: C43H55N4O10P
• MW: 818.89
• Product Categories: Amidite
• Mol File: 163878-63-5.mol

2'-O-MOE-5MeU-3'-phosphoramidite Chemical Properties

• storage temp.: -20°C
• form: Solid
• pka: 9.55±0.10(Predicted)
• color: White to off-white
• InChIKey: YFRRKZDUDXHJNC-UHDLEJOUNA-N
• SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,37,43,r|

Safety Information

• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids

2'-O-MOE-5MeU-3'-phosphoramidite Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

5''-O-DMT-2''-O-methyl-5-methyluridine is a uridine-derived oligonucleoside (U829910) used in the synthetic preparation of nucleic acids.

General Description

2'-O-MOE-5MeU-3'-phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

General Description

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.