4-Amidinophenylmethanesulfonyl fluoride hydrochloride CAS 74938-88-8

Introduction：Basic information about 4-Amidinophenylmethanesulfonyl fluoride hydrochloride CAS 74938-88-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Basic information

• Product Name: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
• Synonyms: APMSF HCL;APMSF HYDROCHLORIDE;4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORI;P-APMSF;P-APMSF, HYDROCHLORIDE;(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE;P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL;P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE
• CAS: 74938-88-8
• MF: C8H10ClFN2O2S
• MW: 252.69
• Product Categories: inhibitor
• Mol File: 74938-88-8.mol

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Chemical Properties

• Melting point: ~205 °C (dec.)
• storage temp.: -20°C
• solubility: H₂O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
• form: White solid
• color: white
• Water Solubility: water: 25mg/mL
• BRN: 9083148
• InChI: 1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
• InChIKey: KHLLRHIUKOJXLL-UHFFFAOYSA-N
• SMILES: Cl[H].NC(=N)c1ccc(CS(F)(=O)=O)cc1
• CAS DataBase Reference: 74938-88-8(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• F: 10-21
• HS Code: 29252900
• Storage Class: 11 - Combustible Solids

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Usage And Synthesis

Description

p-APMSF is an irreversible inhibitor of serine proteases with K_i values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

Uses

p-APMSF is an irreversible inhibitor of serinase. p-APMSFhas substrate specificity for positively charged side chains of amino acids,lysine, or arginine. p-APMSF can be used to study the irreversible inhibitionof trypsin and thrombin [1].

Biochem/physiol Actions

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

References

[1] LauraR, et al. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitorof serine proteases. Biochemistry. 1980 Oct 14;19(21):4859-64. DOI:10.1021/bi00562a024