4-Chloro-3-nitroaniline CAS 635-22-3

Introduction：Basic information about 4-Chloro-3-nitroaniline CAS 635-22-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-Chloro-3-nitroaniline Basic information

• Product Name: 4-Chloro-3-nitroaniline
• Synonyms: 4-chloro-3-nitro-anilin;4-chloro-3-nitro-benzenamin;Aniline, 4-chloro-3-nitro-;benzenamine,-chloro-3-nitro-;5-Amino-2-chloronitrobenzene;4-AMINO-1-CHLORO-2-NITROBENZENE;4-Chloro-3-nitrobenzenamine;4-CHLORO-3-NITROANILINE
• CAS: 635-22-3
• MF: C6H5ClN2O2
• MW: 172.57
• EINECS: 211-231-3
• Product Categories: Amines;Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Intermediates of Dyes and Pigments;Aromatics Compounds
• Mol File: 635-22-3.mol

4-Chloro-3-nitroaniline Chemical Properties

• Melting point: 99-101 °C (lit.)
• Boiling point: 200°C (rough estimate)
• density: 1.5610 (rough estimate)
• refractive index: 1.5870 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• pka: 1.87±0.10(Predicted)
• form: powder to crystal
• color: White to Yellow to Orange
• BRN: 1309394
• InChI: InChI=1S/C6H5ClN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2
• InChIKey: FOHHWGVAOVDVLP-UHFFFAOYSA-N
• SMILES: C1(N)=CC=C(Cl)C([N+]([O-])=O)=C1
• CAS DataBase Reference: 635-22-3(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-chloro-3-nitro-(635-22-3)
• EPA Substance Registry System: 4-Chloro-3-nitroaniline (635-22-3)

Safety Information

• Hazard Codes: T+,N,T
• Risk Statements: 26/27/28-33-51/53
• Safety Statements: 28-36/37-45-61-28A
• RIDADR: UN 2237 6.1/PG 3
• WGK Germany: 3
• RTECS: BX1750000
• Hazard Note: Very Toxic
• TSCA: TSCA listed
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29214210
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
• Hazard Classifications: Acute Tox. 2 Dermal Acute Tox. 2 Inhalation Acute Tox. 4 Oral Aquatic Chronic 2 STOT RE 2
• Hazardous Substances Data: 635-22-3(Hazardous Substances Data)

4-Chloro-3-nitroaniline Usage And Synthesis

Chemical Properties

ochre powder

Uses

Intermediate in the manufacture of azo dyes,pharmaceuticals, and other organic compounds.

Application

Commercial 4-chloro-3-nitroaniline could be used as a starting material for 3-azido-4-chlorophenylisothiocyanate through a 5-step synthesis. In order to research the impact of the strain on the metabolite profile of plasma samples in rats, 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) was evaluated for 4 weeks. 4C3N administration led to extravascular hemolytic anemia with a few metabolome changes, which were strain-dependent [1-2].

Hazard

Toxic by ingestion and inhalation.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx and Cl-.

References

[1] H. Lamotte. “Synthesis of N‐(3‐azido‐4‐chlorophenyl)‐N′‐[3H‐methyl] thiourea, an efficient photoaffinity probe for the urea carrier.” Journal of Labelled Compounds and Radiopharmaceuticals 42 1 (1994): 289–295.
[2] O’Donoghue, John L. “Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.” Fundamental and Applied Toxicology 6 3 (1986): Pages 551-558.

4-Chloro-3-nitroaniline Preparation Products And Raw materials

• Preparation Products: 1-broMo-3-chloro-2-nitrobenzene-->4-Chloro-3-nitrobenzotrifluoride-->4-Chloro-3-nitrobenzenesulfonyl chloride-->(4-chloro-3-nitro-phenyl)arsonic acid-->2'-Chloro-5'-[4-(2,4-di-tert-pentylphenoxy)butyrylamino]-4,4-dimethyl-3-oxopentananilide