Introduction：Basic information about 4-Chloroquinoline CAS 611-35-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Chloroquinoline Basic information
| Product Name: | 4-Chloroquinoline |
| Synonyms: | 4-Chloroquinoline,99%;Butyraldehyde,Butanal;4-Chloroquinoline, 98%+;4-CHLOROQUINOLINE;Quinoline, 4-chloro-;4-Chloroquinoline 97%;oroquinoL;4-CHLOROQUINOLINE ISO 9001：2015 REACH |
| CAS: | 611-35-8 |
| MF: | C9H6ClN |
| MW: | 163.6 |
| EINECS: | 210-267-7 |
| Product Categories: | QuinolinesHeterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines |
| Mol File: | 611-35-8.mol |
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4-Chloroquinoline Chemical Properties
| Melting point | 28-31 °C (lit.) |
| Boiling point | 260-261 °C (lit.) |
| density | 1.25 g/mL at 20 °C (lit.) |
| refractive index | 1.6110 (estimate) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 3.57±0.13(Predicted) |
| form | powder to lump |
| color | White to Almost white |
| Water Solubility | Partly soluble in water. |
| λmax | 316nm(EtOH aq.)(lit.) |
| BRN | 114721 |
| InChI | 1S/C9H6ClN/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H |
| InChIKey | KNDOFJFSHZCKGT-UHFFFAOYSA-N |
| SMILES | Clc1ccnc2ccccc12 |
| CAS DataBase Reference | 611-35-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Chloroquinoline(611-35-8) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
4-Chloroquinoline Usage And Synthesis
| Chemical Properties | Pale yellow low melting solid |
| Uses | 4-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. |
| Purification Methods | Possible impurities include the 2-isomer. It is best purified by converting to the picrate (m 212-213o dec) in EtOH and recrystallising it from EtOH (where the picrate of the 2-chloroquinoline remains in solution) or EtOAc . The picrate is decomposed with 5% aqueous NaOH, extracted in CHCl3, washed with H2O, dried (MgSO4), evaporated and distilled in a vacuum. It can be steam distilled from slightly alkaline aqueous solutions, the aqueous distillate is extracted with Et2O, evaporated and distilled. The distillate solidifies on cooling. [Bobránski Chem Ber 71 578 1938, Beilstein 20/7 V 314.] |
4-Chloroquinoline Preparation Products And Raw materials
| Raw materials | Sodium hydroxide-->Ethyl acetate-->Diethyl ether-->PETROLEUM ETHER-->Phosphorus oxitrichloride-->Chloroform-->Magnesium sulfate-->Triethyl orthoformate-->Aniline-->Diphenyl ether-->2,2-Dimethyl-1,3-dioxane-4,6-dione-->4-Hydroxyquinoline |
| Preparation Products | 4-Methoxyquinoline-->SGI-1027-->4-CHLORO-2-METHYLQUINOLINE-->4-QUINOLINESULFONIC ACID |
