4-FLUORO-2-METHOXYANILINE CAS 450-91-9

Introduction：Basic information about 4-FLUORO-2-METHOXYANILINE CAS 450-91-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-FLUORO-2-METHOXYANILINE Basic information

• Product Name: 4-FLUORO-2-METHOXYANILINE
• Synonyms: 2-Methoxy-4-fluoroaniline;4-FLUORO-2-METHOXYANILINE;4-Fluoro-2-MethoxybenzenaMine;o-Anisidine, 4-fluoro-;4-Fluoro-2-methoxy-phenylamine;4-Fluoro-o-anisidine, 2-Amino-5-fluoroanisole;2-AMino-5-fluoroanisole[4-Fluoro-2-Methoxyaniline];2-Amino-5-fluoroanisole
• CAS: 450-91-9
• MF: C7H8FNO
• MW: 141.14
• EINECS: 814-457-6
• Product Categories: API
• Mol File: 450-91-9.mol

4-FLUORO-2-METHOXYANILINE Chemical Properties

• Boiling point: 215℃ (756 Torr)
• density: 1.176±0.06 g/cm3 (20 ºC 760 Torr)
• refractive index: 1.5400 to 1.5440
• Fp: 79.5±21.8℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• pka: 4.60±0.10(Predicted)
• form: Solid
• color: Colorless to Brown
• InChI: InChI=1S/C7H8FNO/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,9H2,1H3
• InChIKey: BNRRMRUVYDETQC-UHFFFAOYSA-N
• SMILES: C1(N)=CC=C(F)C=C1OC

Safety Information

• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 2921420090

4-FLUORO-2-METHOXYANILINE Usage And Synthesis

Physical Form

Yellow to Orange to Brown Solid or liquid

Application

4-Fluoro-2-methoxyaniline is a useful synthetic intermediate. It is used to prepare ortho-substituted phenylureas as 5-Hydroxytryptamine (5-HT3) receptor antagonists. It is also used to synthesize hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.

Synthesis

Using 4-fluoro-2-o-methoxynitrobenzene as the starting material, the target compound 4-fluoro-2-methoxyaniline was prepared by hydrogenation reduction reaction.

References

[1] Patent: US6352993, 2002, B1. Location in patent: Page column 30
[2] Patent: CN106366072, 2017, A. Location in patent: Paragraph 0062; 0063; 0064; 0090; 0091; 0092
[3] Patent: CN106366022, 2017, A. Location in patent: Paragraph 0051; 0052; 0056
[4] Patent: US2011/130415, 2011, A1. Location in patent: Page/Page column 102
[5] Patent: WO2018/207120, 2018, A1. Location in patent: Page/Page column 11; 12

4-FLUORO-2-METHOXYANILINE Preparation Products And Raw materials

• Raw materials: 5-Fluoro-2-nitroanisole-->Methanol-->Hydrogen
• Preparation Products: 5-Fluoro-2-nitroanisole-->N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine-->AZ 7550-->Quinoline, 6-fluoro-8-methoxy-2-methyl--->2-bromo-4-fluoro-6-methoxyaniline-->4-Fluoro-1-Isocyanato-2-Methoxybenzene(WX681004)-->4-fluoro-2-Methoxy-5-nitroaniline