Introduction：Basic information about ALPHA-BOSWELLIC ACID CAS 471-66-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
ALPHA-BOSWELLIC ACID Basic information
| Product Name: | ALPHA-BOSWELLIC ACID |
| Synonyms: | A-BOSWELLIC ACID;A-ALPHA-BOSWELLIC ACID;ALPHA-BOSWELLIC ACID;BOSWELLIC ACID, A-;BOSWELLIC ACID, a-(SH);3alpha-Hydroxy-12-oleanen-24-oic acid;(3α,4β)-3-Hydroxyolean-12-en-23-oic Acid;3α-hydroxyolean-12-en-24-oic Acid |
| CAS: | 471-66-9 |
| MF: | C30H48O3 |
| MW: | 456.7 |
| EINECS: | |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Natural Products |
| Mol File: | 471-66-9.mol |
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ALPHA-BOSWELLIC ACID Chemical Properties
| Melting point | 289℃ |
| Boiling point | 552.7±50.0 °C(Predicted) |
| density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.50±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | practically insoluble in water |
| BRN | 3074442 |
| Major Application | food and beverages |
| InChIKey | BZXULBWGROURAF-IKNLXHIFSA-N |
| SMILES | CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1 |
| LogP | 9.430 (est) |
Safety Information
| WGK Germany | 3 |
| HS Code | 29181990 |
| Storage Class | 11 - Combustible Solids |
ALPHA-BOSWELLIC ACID Usage And Synthesis
| Chemical Properties | It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from frankincense. |
| Uses | ALPHA-BOSWELLIC ACID is the principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation. |
| in vivo | alpha-Boswellic acid (3 or 10 mg/kg, intraperitoneal injection) decreases epidermal thickening, mast cell count and dermal infiltration in BALB/c mice induced by 2, 4-dinitrochlorobenzene[1].
alpha-Boswellic acid (200 mg/kg, gavage) has a protective effect on ethanol-induced gastric injury in rats[2].
| Animal Model: | 2,4-Dinitrochlorobenzene-Induced Atopic-like Dermatitis in BALB/c Mice[1] | | Dosage: | 3 or 10 mg/kg | | Administration: | i.p. | | Result: | Reduced the severity of the AD-like symptoms.
Attenuated the increase in ear thickness and decreased cutaneous TEWL in DNCB-treated mice.| Animal Model: | Ethanol-induced gastric injury in rats[2] | | Dosage: | 200 mg/kg | | Administration: | i.g. | | Result: | Reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner.
Increased the expression of both Nrf2 and HO-1. |
| | target | NO | PGE | Nrf2 | HO-1 | ROS |
ALPHA-BOSWELLIC ACID Preparation Products And Raw materials |
