Aminopyrazine CAS 5049-61-6
Introduction：Basic information about Aminopyrazine CAS 5049-61-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Aminopyrazine Basic information
| Product Name: | Aminopyrazine |
| Synonyms: | 2-Pyrazinylamine;AMinopyrazine, 99+% 10GR;2-AMINOPYRAZINE FOR SYNTHESIS;Pyrazin-2-amine, 2-Amino-1,4-diazine;APZ;TIMTEC-BB SBB004388;NSC 13147;PYRAZIN-2-AMINE |
| CAS: | 5049-61-6 |
| MF: | C4H5N3 |
| MW: | 95.1 |
| EINECS: | 225-748-7 |
| Product Categories: | pharmacetical;Pyrazine;API intermediates;Pyrazines;Fluorobenzene;Chloropyrazines, etc.;bc0001 |
| Mol File: | 5049-61-6.mol |
Aminopyrazine Chemical Properties
| Melting point | 118-120 °C (lit.) |
| Boiling point | 167.6°C (rough estimate) |
| density | 1.1031 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | 3.22±0.10(Predicted) |
| form | Crystalline Powder |
| color | Slightly yellow to beige |
| Water Solubility | soluble |
| BRN | 107025 |
| InChI | 1S/C4H5N3/c5-4-3-6-1-2-7-4/h1-3H,(H2,5,7) |
| InChIKey | XFTQRUTUGRCSGO-UHFFFAOYSA-N |
| SMILES | Nc1cnccn1 |
| LogP | -0.070 |
| CAS DataBase Reference | 5049-61-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Aminopyrazine(5049-61-6) |
Safety Information
| Hazard Codes | Xi,F |
| Risk Statements | 36/37/38-11 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| HS Code | 29339990 |
| Storage Class | 11 - Combustible Solids |
| Chemical Properties | SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER |
| Uses | 2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines. |
| Application | 2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines. |
| Definition | ChEBI: Aminopyrazine is a member of pyrazines. |
| Synthesis | 19847-12-2 5049-61-6 General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield. |
| References | [1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022 [2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014 |
Aminopyrazine Preparation Products And Raw materials
| Raw materials | 2-Amino-3,5-dibromopyrazine-->BenzeneacetaMide, N-cyclohexyl-α-oxo-GlyoxylaMide, N-cyclohexyl-2-phenyl- (6CI,7CI,8CI)-->Pyrazinemethanol, alpha-methyl- (9CI)-->Pyrazinecarbonitrile-->Lumazine-->2-FLUOROPYRAZINE 98-->Iodopyrazine-->Pyrazinamine, N-pyrazinyl--->1H-Isoindol-1-one, 3-hydroxy--->3-Aminopyrazine-2-carboxylic acid-->Pyrazinamide-->Pyrazine-->2-Chloropyrazine |
| Preparation Products | METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE-->2-Amino-5-bromopyrazine-->2-Amino-3-chloropyrazine-->2-Amino-5-chloropyrazine |
