Amorolfine hydrochloride CAS 78613-38-4

Introduction：Basic information about Amorolfine hydrochloride CAS 78613-38-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Amorolfine hydrochloride Basic information

• Product Name: Amorolfine hydrochloride
• Synonyms: AMOROLFINE HCL;Amorolfine HCI;Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-;Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-;Ro 14-4767/002;(+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine hydrochloride;Amorolfine hydrochloride;(2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
• CAS: 78613-38-4
• MF: C21H36ClNO
• MW: 353.98
• EINECS: 689-236-9
• Product Categories: HYTRIN;Antifungal (Topical);Antifungals for Research and Experimental Use;Biochemistry;78613-38-4
• Mol File: 78613-38-4.mol

Amorolfine hydrochloride Chemical Properties

• Boiling point: 120 C
• storage temp.: room temp
• solubility: DMSO: ≥5mg/mL (warmed)
• form: powder
• color: white to beige
• Major Application: pharmaceutical (small molecule)
• InChI: 1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
• InChIKey: XZKWIPVTHGWDCF-KUZYQSSXSA-N
• SMILES: Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
• CAS DataBase Reference: 78613-38-4(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn,N
• Risk Statements: 20/21/22-36/37/38-50/53-38-22
• Safety Statements: 26-36-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HS Code: 29411010
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Aquatic Chronic 2 Skin Irrit. 2

Amorolfine hydrochloride Usage And Synthesis

Description

Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topicaltreatment of onychomycosis. Mechanistically, it appears to inhibit two stages of theergosterol biosynthetic pathway, which is necessary for fungal cell viability. Activeagainst a broad spectrum of fungi, amorolfiie hydrochloride is particularly effectiveagainst yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.

Chemical Properties

Liquid

Originator

Roche (Switzerland)

Uses

Amorolfine hydrochloride has been used as an antifungal agent.

Uses

antihypertensive

Definition

ChEBI: A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal agnt, it is used for the topical treatment of fungal nail and skin infections.

Brand name

Loceryl (Hoffmann-LaRoche).

Biochem/physiol Actions

Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.