Bis-Propargyl-PEG13 CAS 1351373-50-6

Introduction：Basic information about Bis-Propargyl-PEG13 CAS 1351373-50-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Bis-Propargyl-PEG13 Basic information

• Product Name: Bis-Propargyl-PEG13
• Synonyms: Bis-Propargyl-PEG13;Bis-propargyl-PEG12;CAS_1351373-50-6;4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne;Bis-propargyl-PEG12/4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne;Propargyl-PEG12-Propargyl
• CAS: 1351373-50-6
• MF: C30H54O13
• MW: 622.74
• Mol File: 1351373-50-6.mol

Bis-Propargyl-PEG13 Chemical Properties

• solubility: Soluble in Water, DMSO, DMF, DCM

Bis-Propargyl-PEG13 Usage And Synthesis

Description

Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Uses

Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

IC 50

PEGs

structure and hydrogen bonding

Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005