Introduction：Basic information about Bromfenac Sodium CAS 120638-55-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Bromfenac Sodium Basic information
| Product Name: | Bromfenac Sodium |
| Synonyms: | Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate;Benzeneacetic acid, 2-amino-3-(4-bromobenzoyl)-, monosodium salt, hydrate (2:3);Bromfenac ophthalmic;Bromfenac ophthalmic solution;Duract;Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate;Unii-8ecv571Y37;Bromfenac monosodium salt sesquihydrate |
| CAS: | 120638-55-3 |
| MF: | C15H11BrNNaO3 |
| MW: | 356.15 |
| EINECS: | 695-342-6 |
| Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol File: | 120638-55-3.mol |
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Bromfenac Sodium Chemical Properties
| Melting point | 268-270°C (dec.) |
| storage temp. | Refrigerator |
| solubility | DMSO: ≥ 100 mg/mL (260.98 mM); Water: ≥ 100 mg/mL (260.98 mM) |
| form | Solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19) |
| InChIKey | ZBPLOVFIXSTCRZ-UHFFFAOYSA-N |
| SMILES | C1(=CC=CC(CC(=O)O)=C1N)C(=O)C1=CC=C(Br)C=C1 |
Safety Information
Bromfenac Sodium Usage And Synthesis
| Description | Duract was launched in the US as a potent, orally-active, long lasting peripheralanalgesic with antiinflammatory properties. It is structurally similar to ketoprofen anddiclofenac and can be prepared in three steps from 2-amino-4’-bromophenone usingGassman’s oxindole synthesis. Duract’s biological effects are a result of its ability toreduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromoderivative of Amfenac, this modification increased the duration of analgesic activityand antiinflammatory potency. It was also free of any CNS, cardiovascular orautonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASAand 25 mg was slightly more potent than 400 mg of Ibuprofen. |
| Chemical Properties | Yellow Solid |
| Originator | American Home Products (US) |
| Uses | Bromfenac (Xibrom, ISTA Pharmaceuticals, Irvine, USA; Bronuck, Senju Pharmaceutical, Osaka, Japan) is indicated for the treatment of postoperative inflammation and the reduction of ocular pain in patients after undergoing cataract extraction. For this task, one drop of Xibrom may be applied to the affected eye twice daily beginning 24 hours after cataract surgery and continuing for the first 2 weeks of the postoperative period. The clinical safety and efficacy of bromfenac have been extensively studied in diverse comparative investigations, including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation.The results of two phase III multicenter, randomized double-masked placebo-controlled clinical trials showed that bromfenac ophthalmic solution 0.09% was effective in the rapid resolution of ocular pain after cataract surgery, and there was a statistically significant difference between the bromfenac and placebo groups demonstrated in these phase III clinical trials. |
| Uses | Bromfenac is a non-steroidal anti-inflammatory agent. |
| Definition | ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. |
| Brand name | Xibrom(Ista). |
Bromfenac Sodium Preparation Products And Raw materials
