Chloropyramine CAS 59-32-5

Introduction：Basic information about Chloropyramine CAS 59-32-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Chloropyramine Basic information

• Product Name: Chloropyramine
• Synonyms: 1,2-Ethanediamine, N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-;2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-pyridin;2-((p-Chlorobenzyl)(2-(dimethylamino)ethyl)amino)pyridine;Allergan;Allergan S;n-(p-chlorobenzyl)-n',n'-dimethyl-n-(2-pyridyl)ethylenediamine;CHLOROPYRAMINE BASE;CHLOROPYRAMINE
• CAS: 59-32-5
• MF: C16H20ClN3
• MW: 289.8
• EINECS: 200-421-1
• Mol File: 59-32-5.mol

Chloropyramine Chemical Properties

• Melting point: 25°C
• Boiling point: bp0.2 154-155°
• density: 1.1031 (rough estimate)
• refractive index: 1.6010 (estimate)
• pka: 9.00±0.28(Predicted)
• NIST Chemistry Reference: Chloropyramine(59-32-5)

Chloropyramine Usage And Synthesis

Uses

Chloropyramine is used for allergic dermatosis, allergic rhinitis and conjunctivitis, fordrug-induced allergies, in the beginning stages of bronchial asthma, eczema, neurodermatitis,contact dermatitis, and toxicodermia. It also exhibits a sedative effect. Synonymsof this drug are suprastin, chlortripelenamine, and synopen.

Definition

ChEBI: N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-(2-pyridinyl)ethane-1,2-diamine is an aminopyridine.

Synthesis

Chloropyramine, N-(4-chlorobenzyl)-N??,N??-dimethyl-N-2-pyridylethylenediamine(16.1.9), is synthesized in a somewhat different manner, which is by reacting2-brompyridine with N-(4-chlorobenzyl)-N??,N??-dimethylethylenediamine (16.1.8).N-(4-Chlorobenzyl)-N??,N??-dimethylethylenediamine (16.1.8), in turn, is synthesized bycondensation of 4-chlorobenzaldehyde c N,N-dimethylethylenediamine with subsequentreduction of the imine group.

in vivo

Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats^[2].

• Animal Model: Rats^[2]
• Dosage: 10 mg/kg
• Administration: Intraperitoneal
• Result: Reduced histamine-induced hypothermia.

IC 50

H₁ Receptor

Chloropyramine Preparation Products And Raw materials

• Raw materials: Benzenecarbothioamide, 4-chloro-N-[2-(dimethylamino)ethyl]-N-2-pyridinyl--->1,2-Ethanediamine, N'-[(4-chlorophenyl)methyl]-N,N-dimethyl--->2-(2-pyridylamino)ethyldimethylamine-->(4-CHLORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE-->2-Bromopyridine-->2-Aminopyridine