Desoxypodophyllotoxin CAS 19186-35-7

Introduction：Basic information about Desoxypodophyllotoxin CAS 19186-35-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Desoxypodophyllotoxin Basic information

• Product Name: Desoxypodophyllotoxin
• Synonyms: Desoxypodophyllotoxin;anthric;Anthricin/Deoxypodophyllotoxin;4-Deoxypodophyllotoxin;Furo[3',4':6,7]naphtho[2,3-D]-1,3-dioxol-6(5ah)-one, 5,8,8A,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,(5R,5ar,8ar)-;Nsc403148;Deoxypodophyllotoxin, deoxypodophyllotoxin;Podophyllotoxin 9-Desoxy Impurity
• CAS: 19186-35-7
• MF: C22H22O7
• MW: 398.41
• Mol File: 19186-35-7.mol

Desoxypodophyllotoxin Chemical Properties

• storage temp.: Store at 2-8°C
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: Powder
• Boiling point: 564.5±50.0 °C(Predicted)
• density: 1.304±0.06 g/cm3(Predicted)
• Melting point: 168 °C
• color: White to off-white
• Stability: Hygroscopic
• InChI: InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1
• InChIKey: ZGLXUQQMLLIKAN-SVIJTADQSA-N
• SMILES: O1C2=CC3=C(C=C2OC1)[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)[C@@]1([H])C(=O)OC[C@]1([H])C3

Desoxypodophyllotoxin Usage And Synthesis

Chemical Properties

Colorless prismatic crystals (anhydrous ethanol), soluble in methanol, ethanol, DMSO and other organic solvents, from the rhizomes of Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying.

Uses

4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.

Definition

ChEBI: A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted a position 5 by a 3,4,5-trimethoxyphenyl group.

in vivo

Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively^[1].

• Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells^[1]
• Dosage: 5, 10, and 20 mg/kg
• Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days
• Result: Inhibited the growth of gastric cancer tumors.