Introduction：Basic information about DSPE-PEG-NH2 CAS 474922-26-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
DSPE-PEG-NH2 Basic information
| Product Name: | DSPE-PEG-NH2 |
| Synonyms: | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[aMino(polyethylene glycol)-2000] (aMMoniuM salt);DSPE-PEG-2K-Amine;DSPE-PEG(2000) Amine;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[AMINO(POLYETHYLENE GLYCOL)-2000] (AMMONIUM SALT);DSPE-PEG(2000) AMINE;DSPE-PEG2000-NH2;DSPE-PEG-NH2;DSPE-PEG-NH2 ISO 9001：2015 REACH;Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-(2-aminoethoxy)-, ammonium salt (1:1) |
| CAS: | 474922-26-4 |
| MF: | (C2H4O)nC44H87N2O10P.H3N |
| MW: | 0 |
| EINECS: | |
| Product Categories: | peg |
| Mol File: | 474922-26-4.mol |
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DSPE-PEG-NH2 Chemical Properties
| storage temp. | Store at -20°C |
| solubility | DMF: 11 mg/ml,Ethanol: 20 mg/ml |
| form | Solid |
| color | White to off-white |
| InChIKey | AXHRCGLQEUQOIS-UHFFFAOYSA-N |
| SMILES | C(COC(=O)CCCCCCCCCCCCCCCCC)(OC(=O)CCCCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)O{-}CC{+n}OCCN.N |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
DSPE-PEG-NH2 Usage And Synthesis
| Description | DSPE-PEG-Amine, MW 2,000 is a PEG polymer containing DSPE and amine end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group can react with activated NHS ester to form a stable amide bond. |
| Uses | DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 1000 (ammonium) can be converted to an aromatic aldehyde, which reacts with an acetone-protected aromatic hydrazine on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate. |
| References | [1] Nagata H, et al. Preparation and Catalytic Properties of Carbonic Anhydrase Conjugated to Liposomes through a Bis-Aryl Hydrazone Bond. ACS Omega. 2023 May 16;8(21):18637-18652. DOI:10.1021/acsomega.3c00551 |
DSPE-PEG-NH2 Preparation Products And Raw materials
