| Description | Apiresone is a central skeletal muscle relaxant with various pharmacological effects. Animal experiments suggest that eperisone hydrochloride can dose-dependently inhibit decerebral tonic (γ-rigid) and ischemic decerebral tonic (α-rigid) induced by interthalamic transection in rats, and inhibit the stimulation of the dorsal spinal cord in cats with spinal cord injury. The evoked monosynaptic and polysynaptic reflex potentials may reduce the sensitivity of muscle spindles by inhibiting the γ-neuron system. |
| Pharmacological action | Eperisone is an antispasmodic agent used in the study of disorders characterized by muscle stiffness and pain. It works by relaxing skeletal and vascular smooth muscles, such as reducing muscle tone, improving circulation and suppressing pain reflexes. Eperisone is a centrally acting muscle relaxant that inhibits pain reflex pathways and has vasodilatory effects. |
| Uses | Eperisone is used to improve muscle tension in cervicobrachial syndrome, frozen shoulder, and low back pain; and to treat spastic paralysis in cerebrovascular disorders, postoperative sequelae, cervical spondylosis, spinal vascular disorders, subacute spinal cord optic neuropathy, and other brain and spinal cord diseases. |
| Side effects | Serious adverse reactions include: shock, abnormal liver function, abnormal renal function, abnormal blood picture; the following adverse reactions may occur: skin, rash, itching, etc.; mental nerves, insomnia, headache, drowsiness, body stiffness, numbness of limbs, decreased consciousness, limbs Weakness, unsteady standing, etc.; Digestive system, nausea, vomiting, loss of appetite, stomach discomfort, abnormal liver function, etc.; Urinary system, urinary retention, urinary incontinence, feeling of incomplete urination, etc., occasionally abnormal renal function; systemic symptoms, Fatigue, occasional dizziness, decreased muscle tension, etc.; other, facial flushing, sweating, etc. |
| Originator | Myonal,Eisai,Japan,1983 |
| Definition | ChEBI: 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one is an aromatic ketone that is N-propylpiperidine in which a hydrogen at positon 2 of the propyl group is replaced by a p-ethylbenzoyl group. It is a member of piperidines and an aromatic ketone. |
| Manufacturing Process | To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone,28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and theresulting mixture is heated to reflux on an oil bath with stirring. The heating iscontinued, and when the reaction mixture solidifies, the state being a sign ofcompletion of the reaction, there are added 500 ml of acetone thereinto. Thesolidified mass is pulverized by crush, recovered by filtration and washed withacetone. 144 g of the crude dry crystalline substance is thus obtained, whichis the hydrochloride of the purposed product. The hydrochloride isrecrystallized from isopropanol, and there are obtained the crystalline needleshaving the melting point of 170°C to 172°C. |
| Therapeutic Function | Muscle relaxant |
