Introduction：Basic information about Eperisone hydrochloride CAS 56839-43-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Eperisone hydrochloride Basic information
| Product Name: | Eperisone hydrochloride |
| Synonyms: | EPERISONE HCL;EPERISONE HYDROCHLORIDE;(4'-ethyl-2-methyl-3-piperidino)propiophenone hydrochloride;1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanonhydrochloride;4’-ethyl-2-methyl-3-piperidino-propiophenonhydrochloride;e0646;e-646;empp |
| CAS: | 56839-43-1 |
| MF: | C17H26ClNO |
| MW: | 295.85 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Biochemicals |
| Mol File: | 56839-43-1.mol |
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Eperisone hydrochloride Chemical Properties
| Melting point | 169-171°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| InChI | InChI=1S/C17H25NO.ClH/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18;/h7-10,14H,3-6,11-13H2,1-2H3;1H |
| InChIKey | GTAXGNCCEYZRII-UHFFFAOYSA-N |
| SMILES | C1(=CC=C(CC)C=C1)C(=O)C(C)CN1CCCCC1.Cl |
| CAS DataBase Reference | 56839-43-1(CAS DataBase Reference) |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa) |
Eperisone hydrochloride Usage And Synthesis
| Description | Eperisone hydrochloride is a centrally acting muscle relaxant useful in themanagement of various spastic conditions including cervical spondylosis andcerebral palsy. It is structurally related to tolperisone. |
| Chemical Properties | White Solid |
| Originator | Eisai (Japan) |
| Uses | A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal). |
| Uses | Used as antispasmodic |
| Definition | ChEBI: Eperisone hydrochloride is an aromatic ketone. |
| Manufacturing Process | To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone,28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and theresulting mixture is heated to reflux on an oil bath with stirring. The heating iscontinued, and when the reaction mixture solidifies, the state being a sign ofcompletion of the reaction, there are added 500 ml of acetone thereinto. Thesolidified mass is pulverized by crush, recovered by filtration and washed withacetone. 144 g of the crude dry crystalline substance is thus obtained, whichis the hydrochloride of the purposed product. The hydrochloride isrecrystallized from isopropanol, and there are obtained the crystalline needleshaving the melting point of 170°C to 172°C. |
| Brand name | MYONAL |
| Therapeutic Function | Muscle relaxant |
Eperisone hydrochloride Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Paraformaldehyde-->Piperidine hydrochloride-->4'-Ethylpropiophenone |
