Introduction：Basic information about Eprazinone CAS 10402-90-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Eprazinone Basic informationApplication
| Product Name: | Eprazinone |
| Synonyms: | EPRAZINONE;1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzoyl)propylpiperazine;β-[4-(β-Ethoxyphenethyl)-1-piperazinyl]-α-methylpropiophenone;3-(4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl)-2-Methyl-1-phenylpropan-1-one;1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-;1-(2-phenyl-2-ethoxyethyl)-4-(2-benzyloxypropyl)piperazine;2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-propiophenon;3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propano ne |
| CAS: | 10402-90-1 |
| MF: | C24H32N2O2 |
| MW: | 380.52 |
| EINECS: | 233-873-3 |
| Product Categories: | |
| Mol File: | 10402-90-1.mol |
|
Eprazinone Chemical Properties
| Boiling point | 508.13°C (rough estimate) |
| density | 1.0909 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 6.83±0.10(Predicted) |
| CAS DataBase Reference | 10402-90-1(CAS DataBase Reference) |
Safety Information
Eprazinone Usage And Synthesis
| Application | Epradone is mainly used clinically for coughs caused by acute and chronic bronchitis, pneumonia, asthma, and tuberculosis. |
| Originator | Mucitux,Riom,France,1969 |
| Definition | ChEBI: A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups. |
| Manufacturing Process | 61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g(0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. Theproduct is allowed to crystallize, then filtered and washed with alcohol. It isdried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water.Yield: 66%. Melting point: 160°C. |
| Therapeutic Function | Antitussive |
Eprazinone Preparation Products And Raw materials
| Raw materials | Propiophenone-->Hydrochloric acid-->1,3,5-trioxane |
