Folic acid PEG DSPE CAS 1236288-25-7

Introduction：Basic information about Folic acid PEG DSPE CAS 1236288-25-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Folic acid PEG DSPE Basic information

• Product Name: Folic acid PEG DSPE
• Synonyms: 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[folate(polyethylene glycol)-5000] (aMMoniuM salt);DSPE-PEG(5000) Folate;1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt);1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[FOLATE(POLYETHYLENE GLYCOL)-2000] (AMMONIUM SALT);DSPE-PEG(2000) FOLATE;DSPE-PEG(2000) Folate;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[FOLATE(POLYETHYLENE GLYCOL)-5000] (AMMONIUM SALT);DSPE-PEG(5000) FOLATE;DSPE-PEG-5K-Folate;Folic acid PEG DSPE
• CAS: 1236288-25-7
• MF: (C2H4O)nC63H104N9O15P.2H3N
• MW: 0
• Mol File: 1236288-25-7.mol

Folic acid PEG DSPE Chemical Properties

• storage temp.: -20°C
• form: Solid
• color: Yellow to brown
• InChIKey: ZOYJDPBUYFCOOH-UHFFFAOYSA-N
• SMILES: O=C1N=C(N=C2NC=C(N=C21)CNC1C=CC(=CC=1)C(=O)NC(C(=O)O)CCC(=O)NCCOC{-}CO{+n}C(=O)NCCOP(O)(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC)N.N

Safety Information

• Storage Class: 11 - Combustible Solids

Folic acid PEG DSPE Usage And Synthesis

Uses

DSPE-PEG(5000) Folate may be used:

• in preparation of folate functionalized nanoparticles (NPs)
• in synthesis of BTPEPBI-containing nanoparticles
• in preparation of paclitaxel loaded folate modified lipid-shell and polymer-core nanoparticles (FLPNPs)

Biological Activity

Folate receptors are cellular surface markers for numerous solid tumors. DSPE-PEG-folate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) incorporated into liposomes serves as a targeting ligand. Folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Many molecules such as toxins (proteinaceous), immune stimulators and anti-cancer drugs can be delivered to folate receptor.