garcinone C CAS 76996-27-5

Introduction：Basic information about garcinone C CAS 76996-27-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

garcinone C Basic information

• Product Name: garcinone C
• Synonyms: garcinone C;1,3,6,7-Tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one;9H-Xanthen-9-one,1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-Methylbutyl)-2-(3-Methyl-2-buten-1-yl)-;1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one;1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)-9H-xanthen-9-one;Cyclin dependent kinase,inhibit,Garcinone C,STAT,ATM/ATR,CDK,ATM and RAD3 related,Inhibitor,Ataxia telangiectasia mutated;1,3,6,7-Tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one;Garcinone C-RM
• CAS: 76996-27-5
• MF: C23H26O7
• MW: 414.45
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 76996-27-5.mol

garcinone C Chemical Properties

• Boiling point: 689.0±55.0 °C(Predicted)
• density: 1.367
• storage temp.: 4°C, protect from light
• solubility: ≥ 80mg/mL in DMSO
• pka: 7.13±0.20(Predicted)
• form: Solid
• color: Light yellow to yellow
• InChI: 1S/C23H26O7/c1-11(2)5-6-12-14(24)9-17-19(21(12)27)22(28)18-13(7-8-23(3,4)29)20(26)15(25)10-16(18)30-17/h5,9-10,24-27,29H,6-8H2,1-4H3
• InChIKey: HLOCLVMUASBDDP-UHFFFAOYSA-N
• SMILES: OC1=C(CCC(C)(O)C)C2=C(C=C1O)OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O

Safety Information

• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids

garcinone C Usage And Synthesis

Uses

Garcinone C is isolated from the pericarps of Garcinia mangostana Linn which has multifunctional activities against Alzheimer’s disease (AD). Acetylcholinesterase inhibitor.

Definition

ChEBI: Garcinone C is a member of xanthones.

in vivo

Garcinone C (10-50 mg/kg, po, 5 days per week for 9 weeks) exhibits antitumor activity in AOM (HY-111375)/DSS (HY-116282C)-induced colon cancer mouse models^[2].

• Animal Model: AOM/DSS-induced colon cancer mouse models^[2]
• Dosage: 10-50 mg/kg
• Administration: po, 5 days per week for 9 weeks
• Result: Reduced the number of colon tumors.

IC 50

ATR; Stat-3; CDK7