H-PHE-NH2 CAS 5241-58-7

Introduction：Basic information about H-PHE-NH2 CAS 5241-58-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

H-PHE-NH2 Basic information

• Product Name: H-PHE-NH2
• Synonyms: H-PHE-NH2;H-L-PHE-NH2;L-PHENYLALANINE AMIDE;L-PHENYLALANINAMIDE;PHENYLALANINE-NH2;L-Phe-NH2;(S)-2-Amino-3-phenylpropionyl amide;2-Amino-3-phenylpropanamideH-Phe-NH2
• CAS: 5241-58-7
• MF: C9H12N2O
• MW: 164.2
• Product Categories: Amino Acids & Derivatives;Aromatics;Chiral Reagents;Phenylalanine [Phe, F];Amino Acids and Derivatives;Amino Acid Derivatives;Peptide Synthesis;Phenylalanine;Amino Acids;I - Z;Modified Amino Acids
• Mol File: 5241-58-7.mol

H-PHE-NH2 Chemical Properties

• Melting point: 93-95°C
• Boiling point: 356.9±35.0 °C(Predicted)
• density: 1.143±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• pka: 15.85±0.50(Predicted)
• form: Powder
• color: White
• Optical Rotation: Consistent with structure
• BRN: 6270941
• Major Application: detection
• InChI: 1S/C9H12N2O/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H2,11,12)/t8-/m0/s1
• InChIKey: OBSIQMZKFXFYLV-QMMMGPOBSA-N
• SMILES: N[C@@H](Cc1ccccc1)C(N)=O
• CAS DataBase Reference: 5241-58-7(CAS DataBase Reference)

Safety Information

• WGK Germany: 3
• HazardClass: IRRITANT
• Storage Class: 13 - Non Combustible Solids

H-PHE-NH2 Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Protected amino acid

Definition

ChEBI: An amino acid amide derived from L-phenylalanine.

Biological Activity

L-Phenylalaninamide is a chiral selector.

Synthesis

7524-50-7

5241-58-7

General procedure for the synthesis of (S)-2-amino-3-phenylpropionamide from L-phenylalanine methyl ester hydrochloride: intermediate 1 (L-phenylalanine methyl ester hydrochloride) was dissolved in 20% aqueous ammonia solution and the reaction was stirred for 20 hours at room temperature. Upon completion of the reaction, 50 mL of ethyl acetate was added to the reaction mixture and three extraction operations were performed. All organic phases were combined and the solvent was removed by rotary evaporator to afford Intermediate 2 ((S)-2-amino-3-phenylpropionamide) as a white solid in 2.5 g yield, 76%.

References

[1] Helvetica Chimica Acta, 2004, vol. 87, # 5, p. 1077 - 1089
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 6074 - 6086
[3] Chemistry - An Asian Journal, 2011, vol. 6, # 6, p. 1321 - 1324
[4] Bulletin de la Societe Chimique de France, 1989, # 5, p. 673 - 676
[5] Patent: CN108610292, 2018, A. Location in patent: Paragraph 0041; 0051; 0052

H-PHE-NH2 Preparation Products And Raw materials

• Raw materials: methyl 3-phenyl-L-alaninate-->Methyl L-phenylalaninate hydrochloride
• Preparation Products: Nalpha-Cbz-L-Arginine-->N-Cbz-L-Leucine-->(1-amino-3-phenylpropan-2-yl)(methyl)amine