| Description | Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction[1]. |
| Chemical Properties | White or almost white, crystalline powder. |
| Uses | Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. |
| Uses | Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP. |
| Definition | ChEBI: DL-Isoprenaline hydrochloride is a member of catechols. |
| Brand name | Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo-ISO (Fisons). |
| General Description | Isoproterenol hydrochloride is an odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. (NTP, 1992) |
| Air & Water Reactions | May be sensitive to exposure to air and light. . Water soluble. |
| Reactivity Profile | An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. |
| Health Hazard | SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating. |
| Fire Hazard | Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible. |
| Biological Activity | Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ . |
| Biochem/physiol Actions | β-adrenoceptor agonist; increases cytosolic cAMP. |
| storage | Store at RT |
| References | [1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19. |
