Introduction：Basic information about Isoprenaline sulphate CAS 299-95-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Isoprenaline sulphate Basic information
| Product Name: | Isoprenaline sulphate |
| Synonyms: | 1-(3,4-DIHYDROXYPHENYL)-2-ISOPROPYLAMINOETHANOL HEMISULFATE SALT;Isoprenaline sulfuric acid;Isoproterenol sulfuric acid;4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol sulfate (2:1);dl-a-3,4-Dihydroxyphenyl-b-iso-propylaminoethanol sulfate;dl-Isoprenaline sulfate;dl-Isoproterenol sulfate |
| CAS: | 299-95-6 |
| MF: | 2C11H17NO3.H2O4S |
| MW: | 520.6 |
| EINECS: | 206-085-2 |
| Product Categories: | |
| Mol File: | 299-95-6.mol |
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Isoprenaline sulphate Chemical Properties
| Melting point | 180 °C |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | almost transparency |
Safety Information
| Risk Statements | 22 |
| Safety Statements | 44 |
| RTECS | DO2273000 |
| HS Code | 29072990 |
| Toxicity | dog,LD50,intravenous,50mg/kg (50mg/kg),Drugs in Japan Vol. 6, Pg. 75, 1982. |
Isoprenaline sulphate Usage And Synthesis
| Originator | Isonorin,Smith, Miller and Patch,US,1949 |
| Uses | Bronchodilator. |
| Manufacturing Process | As described in US Patent 2,308,232, 100 g 3,4-dihydroxy-ω-chloroacetophenone, 200 cc ethyl alcohol and 200 cc of about 50% aqueousisopropylamine solution are boiled during 3 hours on the water bath with theuse of a reflux condenser, whereupon neutralizing with diluted sulfuric acid iscarried out and the sulfate, obtained upon cooling, from alcohol of 50% isrecrystallized; its MP is 245°C.
21 g 3,4-dihydroxy-ω-isopropylaminoacetophenone sulfate are hydrogenatedwith 50 cc methyl alcohol and 50 cc water, 0.5 g carbon and 3 cc palladiumchloride solution of 2%. After 2 hours the hydrogen absorption comes to astandstill, after the theoretical quantity of hydrogen has been absorbed. Afterconcentrating, the isopropylaminomethyl-(3,4-dihydroxyphenyl)carbinolsulfatecrystallizes out. It has a MP of 180°C after refining. |
| Brand name | Medihaler-ISO (3M Pharmaceuticals). |
| Therapeutic Function | Bronchodilator |
Isoprenaline sulphate Preparation Products And Raw materials
| Raw materials | Sulfuric acid-->Isopropylamine-->Hydrogen-->3,4-dihydroxy--chloroacetophenone |
