Introduction：Basic information about Isosorbide CAS 652-67-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Isosorbide Basic information
| Product Name: | Isosorbide |
| Synonyms: | Dianhydro-D-glucitol 98%;1,4:3,6-DIANHYDRO-D-SORBITOL;1,4:3,6-DIANHYDROGLUCITOL;1,4:3,6-DIANHYDROSORBITOL;1,4:3,6-DIANHYDRO-D-GLUCITOL;D-ISOSORBIDE;DIANHYDRO-D-GLUCITOL;DIANHYDRO-D-SORBITOL |
| CAS: | 652-67-5 |
| MF: | C6H10O4 |
| MW: | 146.14 |
| EINECS: | 211-492-3 |
| Product Categories: | Carbohydrates & Derivatives;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;11;Food Additivies;Inhibitors;652-67-5 |
| Mol File: | 652-67-5.mol |
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Isosorbide Chemical Properties
| Melting point | 60-63 °C (lit.) |
| alpha | 42 º (c=3, H2O) |
| Boiling point | 175°C/2mmHg(lit.) |
| density | 1.0945 (rough estimate) |
| vapor pressure | 0.007Pa at 20℃ |
| refractive index | 45 ° (C=5, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 13.17±0.40(Predicted) |
| form | Crystals, Crystalline Solid or Mass |
| color | Off-white to light yellow or beige |
| Optical Rotation | [α]20/D +45.2°, c = 3 in H2O |
| Water Solubility | Soluble in alcohols, water and ketones. |
| Sensitive | Hygroscopic |
| Merck | 14,5224 |
| BRN | 80510 |
| Cosmetics Ingredients Functions | SKIN CONDITIONING
HUMECTANT |
| InChI | 1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1 |
| InChIKey | KLDXJTOLSGUMSJ-JGWLITMVSA-N |
| SMILES | O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12 |
| LogP | -1.39 at 20℃ |
| CAS DataBase Reference | 652-67-5(CAS DataBase Reference) |
| EPA Substance Registry System | D-Glucitol, 1,4:3,6-dianhydro- (652-67-5) |
Safety Information
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | LZ4380000 |
| TSCA | TSCA listed |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 652-67-5(Hazardous Substances Data) |
Isosorbide Usage And Synthesis
| Chemical Properties | off-white to light yellow or beige crystals, |
| Uses | Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators. |
| Uses | pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics. |
| Uses | D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters. |
| Definition | A polyol with a hydroxyl group attached to each oftwo cis-oriented saturated furan rings. Intermediatefor pharmaceuticals. Combustible. |
| Brand name | Ismotic (Alcon). |
| Biological Functions | emergency treatment of acute angle-closure glaucoma.It should not be confused with isosorbide dinitrate, anantianginal drug. |
| Flammability and Explosibility | Non flammable |
| Clinical Use | Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, itsophthalmologic properties are its primary value. |
| Synthesis | Isosorbide can be obtained by catalytic dehydration of sorbitol, sorbitol can be converted from starch, sucrose, glucose and other renewable resources, and has long been large-scale industrialized production, process maturity, cheap. |
Isosorbide Preparation Products And Raw materials
| Raw materials | Sorbitol-->D-Sorbitol-->D-Glucitol, 3,6-anhydro- |
| Preparation Products | Isosorbide dimethyl ether-->D-Iditol, 2,5-anhydro--->Hexitol, 2,5-anhydro--->1.3.7-OCTATRIENE-->Tetrahydrofuran-->2,2-DIMETHYL-4-(2-OXIRANYL)TETRAHYDROFURO[3,4-D][1,3]DIOXOLE-->Isosorbide 5-mononitrate |
