Introduction：Basic information about CAS 16106-20-0|isosorbide 2-mononitrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | isosorbide 2-mononitrate |
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| CAS Number | 16106-20-0 | Molecular Weight | 191.13900 |
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| Density | 1.56g/cm3 | Boiling Point | 364.5ºC at 760mmHg |
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| Molecular Formula | C6H9NO6 | Melting Point | >51.5°C |
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| MSDS | / | Flash Point | 174.2ºC |
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Names
| Name | [(3R,3aR,6S,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.56g/cm3 |
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| Boiling Point | 364.5ºC at 760mmHg |
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| Melting Point | >51.5°C |
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| Molecular Formula | C6H9NO6 |
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| Molecular Weight | 191.13900 |
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| Flash Point | 174.2ºC |
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| Exact Mass | 191.04300 |
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| PSA | 93.74000 |
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| Vapour Pressure | 8.66E-07mmHg at 25°C |
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| Index of Refraction | 1.542 |
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| InChIKey | YWXYYJSYQOXTPL-JGWLITMVSA-N |
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| SMILES | O=[N+]([O-])OC1COC2C(O)COC12 |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LZ4385500
- CAS REGISTRY NUMBER :
- 16106-20-0
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C6-H9-N-O6
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,4947,1985
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Safety Information
| Hazard Codes | F |
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| RTECS | LZ4385500 |
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Articles25
More Articles
| Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on isolated dog aorta: vascular relaxation and increase in cyclic GMP. Arch. Int. Pharmacodyn. Ther. 312 , 104-9, (1991) The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects ... | |
| Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats. J. Pharmacol. Exp. Ther. 261(2) , 692-700, (1992) Conflicting information existed regarding the relevance of pharmacokinetics in relation to the duration of action of organic nitrates. We examined this question using three geometric isomers of organi... | |
| [Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation]. Arzneimittelforschung 47(6) , 719-26, (1997) An investigation in the bioequivalence of a new tablet formulation with 5 mg isosorbide dinitrate (CAS 87-33-2, ISDN 5 von ct) was performed in a two-way cross-over study with 18 subjects. The relativ... | |
Synonyms
| 2-Ismn |
| Glucitol,1,4:3,6-dianhydro-,2-nitrate,D |
| 1,4:3,6-Dianhydrosorbitol 2-mononitrate |
| Isosorbide-5-nitrate |
| isosorbide-5-mononitrate |
| Isosorbide 2-nitrate |
| Isosorbide-2-mononitrate |
| 1,4:3,6-Dianhydro-D-glucitol 2-nitrate |
