Introduction：Basic information about LOBELINE SULFATE CAS 134-64-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
LOBELINE SULFATE Basic information
| Product Name: | LOBELINE SULFATE |
| Synonyms: | 2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone sulfate;2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-ethanon[2;6alpha(s)]]-theta-[2alphsulfate(2:1)(salt);bantron;lobeline,sulfate(2:1)(salt);lobelinsulfate;LOBELINE SULFATE;LOBELINE SULPHATE |
| CAS: | 134-64-5 |
| MF: | C44H56N2O8S |
| MW: | 772.99 |
| EINECS: | 205-151-8 |
| Product Categories: | Alkaloids;Biochemistry;Pyridine Alkaloids |
| Mol File: | 134-64-5.mol |
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LOBELINE SULFATE Chemical Properties
| Melting point | 152-154 °C |
| alpha | D20 -25° (c = 2) |
| density | 1.0400 (rough estimate) |
| refractive index | 1.6900 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 100 mg/mL (129.37 mM);Ethanol: 100 mg/mL (129.37 mM) |
| Water Solubility | Water: 100 mg/mL (129.37 mM) |
| Merck | 5551 |
| CAS DataBase Reference | 134-64-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 45-38-36/37/39-28A |
| RIDADR | 2811 |
| RTECS | OJ8490170 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29399900 |
| Toxicity | mouse,LD50,intraperitoneal,55300ug/kg (55.3mg/kg),Veterinary and Human Toxicology. Vol. 27, Pg. 1, 1985. |
LOBELINE SULFATE Usage And Synthesis
| Chemical Properties | white powder |
| Uses | Lobeline perturbs intra- and extra-cellular neurotransmitter levels and diminishes the in vitro and in vivo effects of psychostimulants. |
| in vivo | Lobeline (0.3-3.0 mg/kg; s.c.; single dose) sulfate decreases d-methamphetamine self-administration in rats model[3].
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) sulfate specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3].
| Animal Model: | Sprague-Dawley rats (200-250 g)[3] | | Dosage: | 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration | | Administration: | Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration | | Result: | Decreased d-methamphetamine Self-Administration. |
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LOBELINE SULFATE Preparation Products And Raw materials
