Introduction：Basic information about CAS 134-64-5|Lobeline sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lobeline sulfate |
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| CAS Number | 134-64-5 | Molecular Weight | 772.98900 |
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| Density | 1.085g/cm3 | Boiling Point | 485.6ºC at 760mmHg |
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| Molecular Formula | C44H56N2O8S | Melting Point | 152-154 °C |
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| MSDS | ChineseUSA | Flash Point | 247.5ºC |
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Names
| Name | lobeline sulfate |
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| Synonym | More Synonyms |
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Lobeline sulfate BiologicalActivity
| Description | Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation[1][2]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| Target | IC50: endogenous metabolite[1] |
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| References | [1]. Robert J. Laffan, et al.EMETIC ACTION OF NICOTINE AND LOBELINE. Journal of Pharmacology and Experimental Therapeutics December 1957, 121 (4) 468-476 [2]. https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st |
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Chemical & Physical Properties
| Density | 1.085g/cm3 |
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| Boiling Point | 485.6ºC at 760mmHg |
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| Melting Point | 152-154 °C |
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| Molecular Formula | C44H56N2O8S |
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| Molecular Weight | 772.98900 |
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| Flash Point | 247.5ºC |
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| Exact Mass | 772.37600 |
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| PSA | 164.06000 |
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| LogP | 8.77580 |
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| Vapour Pressure | 3.05E-10mmHg at 25°C |
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| InChIKey | BEDBXOIWRNCGAU-NFQNBQCWSA-N |
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| SMILES | CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.O=S(=O)(O)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OJ8490170
- CAS REGISTRY NUMBER :
- 134-64-5
- LAST UPDATED :
- 198609
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H27-N-O2.1/2H2-O4-S
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 27,1,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 54600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
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Safety Information
| Hazard Codes | T:Toxic; |
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| Risk Phrases | R23/24/25 |
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| Safety Phrases | S45-S38-S36/37/39-S28A |
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| RIDADR | 2811 |
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| RTECS | OJ8490170 |
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| Packaging Group | III |
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| Hazard Class | 6.1 |
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| HS Code | 2933399090 |
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Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Lobeline sulfate |
| EINECS 205-151-8 |
| MFCD00135592 |
| 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone,sulfuric acid |
