Introduction：Basic information about N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 CAS 2107273-76-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Basic information
| Product Name: | N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 |
| Synonyms: | N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 |
| CAS: | 2107273-76-5 |
| MF: | C63H79ClN4O10 |
| MW: | 1087.79 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 2107273-76-5.mol |
|
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Chemical Properties
| solubility | Soluble in DMSO, DMF, DCM |
Safety Information
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Usage And Synthesis
| Description | N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a Cy5 labeled fluorescent PEG linker containinig DBCO group, which reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. DBCO-activated fluorescein dye will be an ideal alternative to copper intolerant applications. The hydrophilic PEG spacer increases solubility in aqueous media. |
| Uses | N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. |
| IC 50 | PEGs |
| References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Preparation Products And Raw materials
