Introduction：Basic information about naftazone CAS 15687-37-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
naftazone Basic information
| Product Name: | naftazone |
| Synonyms: | naftazone;2-[1-Oxonaphthalen-2(1H)-ylidene]hydrazinecarboxamide;Karbinone;Mediaven;1,2-naphthoquinone semicarbazone;Naftazone-d6;Hydrazinecarboxamide, 2-(1-oxo-2(1H)-naphthalenylidene)-;naftazone USP/EP/BP |
| CAS: | 15687-37-3 |
| MF: | C11H9N3O2 |
| MW: | 215.21 |
| EINECS: | 2397851 |
| Product Categories: | ACTIVE PHARMACEUTICAL INGREDIENTS |
| Mol File: | 15687-37-3.mol |
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naftazone Chemical Properties
| density | 1.40±0.1 g/cm3(Predicted) |
| pka | 12.93±0.20(Predicted) |
| form | Solid |
| color | Yellow to orange |
Safety Information
naftazone Usage And Synthesis
| Uses | 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure. |
| Definition | ChEBI: Naftazone is a member of naphthalenes. |
| in vivo | Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2]. | Animal Model: | Male rats[1] | | Dosage: | 10 and 100 mg/kg | | Administration: | Oral gavage; 10 and 100 mg/kg once per day; for 15 days | | Result: | Significantly reduced glutamate content in cerebro spinal fluid of rats.| Animal Model: | Wistar rats[2] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal injection ; 50 mg/kg once daily for 5 days | | Result: | Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet. |
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naftazone Preparation Products And Raw materials| Raw materials | Semicarbazide hydrochloride-->1,2-NAPHTHOQUINONE |
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