NARIRUTIN CAS 14259-46-2

Introduction：Basic information about NARIRUTIN CAS 14259-46-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

NARIRUTIN Basic information

• Product Name: NARIRUTIN
• Synonyms: NARIRUTIN;NARINGENIN-7-RUTINOSIDE;NARINGENIN-7-O-RUTINOSIDE;ISONARINGIN;(S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-;NARIRUTIN hplc;NARIRUTIN WITH HPLC
• CAS: 14259-46-2
• MF: C27H32O14
• MW: 580.53
• EINECS: 238-138-0
• Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 14259-46-2.mol

NARIRUTIN Chemical Properties

• Melting point: 162-164°C
• Boiling point: 924.3±65.0 °C(Predicted)
• density: 1.66±0.1 g/cm3(Predicted)
• FEMA: 2769 | NARINGEN EXTRACT (CITRUS PARADISI MACF.)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO, Methanol
• form: Solid
• pka: 7.18±0.40(Predicted)
• color: Pale Yellow
• Odor: bland
• Major Application: metabolomics vitamins, nutraceuticals, and natural products
• Cosmetics Ingredients Functions: ANTIOXIDANT
• InChIKey: HXTFHSYLYXVTHC-MSTHVRLMSA-N
• SMILES: C1C(O[C@@H]2OC(CO[C@@H]3OC(C)[C@H](O)[C@H](O)C3O)[C@@H](O)[C@@H](O)C2O)=CC2OC(C3C=CC(O)=CC=3)CC(=O)C=2C=1O
• LogP: 2.07

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: WGK 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

NARIRUTIN Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

(2S)-Narirutin is a naturally occurring flavonoid that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties.

Definition

ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a lycosidic linkage.

Biological Activity

Narirutin is known to possess anti-allergic, anti-inflammatory, antioxidant, and anti-proliferative properties. It inhibits allergic eosinophilic airway inflammation in the mouse model. Narirutin also inhibits lipopolysaccharide (LPS)-induced inflammatory response by inhibiting nuclear factor-KB (NF-KB) and mitogen-activated protein kinases (MAPKs). It displays antioxidant and protective effects on attenuating alcohol-induced liver damage while co-consumed with alcohol in mice model, and can be useful in Alzheimerμs disease (AD) therapeutics.

in vivo

Narirutin (10 mg/kg, p.o ) reduces eosinophil counts in peripheral blood in OVA-challenged mice^[2].
Narirutin (10 mg/kg, p.o ) block the OVA-induced increase in IL-4 but has no effect on the increase in IL-5^[2].

• Animal Model: Allergic asthma female NC/Nga mice model^[2]
• Dosage: 0.1, 1 or 10 mg/kg
• Administration: Orally, 7d
• Result: Reduced eosinophil counts in peripheral blood. Blocked the OVA-induced increase in IL-4.