Oxyresveratrol CAS 29700-22-9

Introduction：Basic information about Oxyresveratrol CAS 29700-22-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Oxyresveratrol Basic information

• Product Name: Oxyresveratrol
• Synonyms: 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol;4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol;Oxyresveratrol ,4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol;Oxyresveratrol;1G/25G/1KG;2,3',4,5'-Tetrahydroxy-trans-stilbene;25g;(E)-4-(3,5-dihydroxystyryl)benzene-1,3-diol
• CAS: 29700-22-9
• MF: C14H12O4
• MW: 244.24
• EINECS: 608-401-8
• Product Categories: API;reagent;standard substance;APIs;29700-22-9
• Mol File: 29700-22-9.mol

Oxyresveratrol Chemical Properties

• Melting point: 201-202.5 °C
• Boiling point: 523.8±30.0 °C(Predicted)
• density: 1.468±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Ethyl Acetate (Slightly), Methanol
• pka: 9.14±0.10(Predicted)
• form: Solid
• color: Pale Yellow to Pale Beige
• Major Application: metabolomics vitamins, nutraceuticals, and natural products
• Cosmetics Ingredients Functions: SKIN PROTECTING BLEACHING SKIN CONDITIONING
• InChI: InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+
• InChIKey: PDHAOJSHSJQANO-OWOJBTEDSA-N
• SMILES: C1(O)=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C(O)=C1
• CAS DataBase Reference: 29700-22-9(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36
• Safety Statements: 26-24/25
• WGK Germany: 3
• HS Code: 29072990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Dam. 1 Skin Irrit. 2 STOT SE 3

Oxyresveratrol Usage And Synthesis

Description

Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects.

Chemical Properties

White powder

Uses

Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent.

Definition

ChEBI: Oxyresveratrol is a stilbenoid.

Biological Activity

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM)
In vitro:
1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.
2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity.
3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.
In vivo:
1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.
2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats.

Solubility in organics

Oxyresveratrol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of oxyresveratrol in these solvents is approximately 50 mg/ml.