Introduction：Basic information about Polydatin CAS 27208-80-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Polydatin Basic information
| Product Name: | Polydatin |
| Synonyms: | RESVERATROL GLUCOSIDE;RESVERATROL-3-B-D-GLUCOSIDE;RESVERATROL 3-BETA-MONO-D-GLUCOSIDE;TRANS-RESVERATROL 3-O-BETA-D-GLUCURONIDE;TRANS-RESVERATROL-O-BETA-GLUCOSIDE;3-Hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl-beta-D-glucopyranoside;3-HYDROXY-5-(2-(4-HYDROXYPHENYL)ETHENYL)PHENYL-BETA-D-GLUCOSIDE;3, 5, 4'-trihydroxystilbene 3-glucoside |
| CAS: | 27208-80-6 |
| MF: | C20H22O8 |
| MW: | 390.39 |
| EINECS: | |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Nutritional Ingredients;Aromatics;Glucuronides;Heterocycles;Anthocyanins;The group of Polydatin |
| Mol File: | 27208-80-6.mol |
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Polydatin Chemical Properties
| Melting point | 223-226 °C(lit.) |
| Boiling point | 707.7±60.0 °C(Predicted) |
| alpha | -77.5 º (c=0.2, EtOH) |
| density | 1.521±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO, Ethanol, Methanol |
| pka | 9.21±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| λmax | 305nm(EtOH)(lit.) |
| Major Application | food and beverages |
| InChI | InChI=1/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/s3 |
| InChIKey | HSTZMXCBWJGKHG-RPHGGTSJNA-N |
| SMILES | O(C1C=C(O)C=C(/C=C/C2C=CC(O)=CC=2)C=1)[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O |&1:17,18,19,21,23,r| |
| LogP | 0.412 (est) |
| CAS DataBase Reference | 27208-80-6(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 |
Polydatin Usage And Synthesis
| Description | Polydatin is a stilbene glucoside and a precursor to trans-resveratrol (Item No. 70675) that has been found in V. vinifera and has diverse biological activities. It scavenges DPPH radicals and inhibits copper-induced lipid peroxidation (IC50s = 198 and 19.1 μM, respectively). Polydatin inhibits the proliferation of, and induces cell cycle arrest at the S phase in, Caco-2 colon cancer cells. It decreases infarct size, cardiomyocyte fibrosis, and apoptosis in a mouse model of myocardial ischemia-reperfusion injury induced by left anterior descending (LAD) coronary artery occlusion when administered at a dose of 40 mg/kg per day. |
| Chemical Properties | Off-White Solid |
| Uses | A Stilbenoid glucoside and is a major Resveratrol derivative. |
| Uses | antioxidant |
| Definition | ChEBI: A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. |
| General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
| References | [1] PIERRE WAFFO TEGUO. Isolation, Identification, and Antioxidant Activity of Three Stilbene Glucosides Newly Extracted from Vitis vinifera Cell Cultures[J]. Journal of Natural Products , 1998, 61 5: 655-657. DOI: 10.1021/np9704819
[2] SALVATORE DE MARIA. Polydatin, a natural precursor of resveratrol, induces cell cycle arrest and differentiation of human colorectal Caco-2 cell.[J]. Journal of Translational Medicine, 2013: 264. DOI: 10.1186/1479-5876-11-264
[3] MING D, SONGYAN L, YAWEN C, et al. trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin–angiotensin system (RAS) and Rho kinase (ROCK) activity?[J]. Food & Function, 2017, 6: 2309-2321. DOI: 10.1039/c6fo01842d |
Polydatin Preparation Products And Raw materials
