Polyoxyethylene stearate CAS 9004-99-3
Introduction：Basic information about Polyoxyethylene stearate CAS 9004-99-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Polyoxyethylene stearate Basic information
| Product Name: | Polyoxyethylene stearate |
| Synonyms: | MYRJ(TM) 53;MYRJ(TM) 59;MYRJ 58;MYRJ 59;MYRJ(R) 53;MYRJ(TM) 45;MYRJ 45;PEG 200 STEARATE |
| CAS: | 9004-99-3 |
| MF: | (C2H4O)nC18H36O2 |
| MW: | 622.91 |
| EINECS: | 618-405-1 |
| Product Categories: | Ester Type (Surfactants);Ethylene Glycols & Monofunctional Ethylene Glycols;Functional Materials;Monofunctional Ethylene Glycols;Nonionic Surfactants;Surfactants;solvent;Cosmetic Ingredients & Chemicals;bc0001 |
| Mol File: | 9004-99-3.mol |
Polyoxyethylene stearate Chemical Properties
| Melting point | 47 °C |
| Fp | 39 °C |
| storage temp. | 2-8°C |
| Water Solubility | Soluble in water |
| solubility | Chloroform (Slighty), Methanol (Slightly) |
| form | powder to lump |
| color | White to Almost white |
| Odor | at 100.00?%. mild fatty |
| Hydrophilic-Lipophilic Balance (HLB) | 18.8 |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions | SURFACTANT - EMULSIFYING HUMECTANT CLEANSING SURFACTANT - CLEANSING |
| Cosmetic Ingredient Review (CIR) | Polyoxyethylene stearate (9004-99-3) |
| InChI | 1S/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3 |
| InChIKey | RFVNOJDQRGSOEL-UHFFFAOYSA-N |
| SMILES | O(CCO)C(=O)CCCCCCCCCCCCCCCCC |
| LogP | 7.629 (est) |
| EPA Substance Registry System | Polyethylene glycol monostearate (9004-99-3) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| RTECS | MD0907300 |
| TSCA | TSCA listed |
| HS Code | 3907200000 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 9004-99-3(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: > 12mL/kg |
| Chemical Properties | Waxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils. |
| Uses | Polyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces. |
| Uses | Pegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants. Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier). Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper. PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams. |
| Definition | Polyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units. |
| Brand name | Myrj 53 (ICI Americas). |
| General Description | Polyoxyethylene (40) stearate is a neutral surfactant. |
| Safety Profile | Very slightly toxic byingestion. Questionable carcinogen withexperimental tumorigenic data.Experimental reproductive effects. Whenheated to decomposition it emits acridsmoke and irritating fumes. See also otherpolyethylene glycol monostearate entries andPOLYETHYLENE GLYCOL. |
| in vitro | Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate. |
| in vivo | Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). |
Polyoxyethylene stearate Preparation Products And Raw materials
| Raw materials | Stearic acid-->Polyethylene Glycol-->Glycerol tristearate |
| Preparation Products | defoaming agent TS-103 |
