POLYPHYLLIN D CAS 50773-41-6

Introduction：Basic information about POLYPHYLLIN D CAS 50773-41-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

POLYPHYLLIN D Basic information

• Product Name: POLYPHYLLIN D
• Synonyms: POLYPHYLLIN D;Polyphyllin;Polyphyllin I;Polyphyllin C;Paris saponin Pa;Polyphillin D;Polyphyllin A;Paridis saponin I
• CAS: 50773-41-6
• MF: C44H70O16
• MW: 855.02
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 50773-41-6.mol

POLYPHYLLIN D Chemical Properties

• Melting point: >245°C (dec.)
• density: 1.40
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
• pka: 12?+-.0.70(Predicted)
• form: Solid
• color: White
• Major Application: food and beverages pharmaceutical
• InChIKey: LRRDDWMXYOSKIC-IPKCVOQPSA-N

Safety Information

• WGK Germany: WGK 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

POLYPHYLLIN D Usage And Synthesis

Description

Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC₅₀s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.

Chemical Properties

White crystalline powder, easily soluble in methanol and water, derived from Paris polyphylla.

Uses

Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.

in vivo

Polyphyllin I (1.5 mg/kg; i.p. twice daily from day 2 to day 11) significantly inhibit the tumor growth of A549 cells in the nude mice^[1].

• Animal Model: BALB/c nude mice (5 weeks old) were s.c. inoculated with A549 cells^[1]
• Dosage: 1.5 mg/kg
• Administration: I.p. twice daily from day 2 to day 11
• Result: The tumor growth rate was much lower than that in cisplatin group and PBSgroup.

References

[1] MEI-SZE LEE. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.[J]. Cancer Biology & Therapy, 2005, 4 11: 1248-1254. DOI: 10.4161/cbt.4.11.2136
[2] ROSE C.Y. ONG . Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells[J]. Cancer letters, 2008, 261 2: Pages 158-164. DOI: 10.1016/j.canlet.2007.11.005