Introduction： Basic information about CAS 968-81-0|Acetohexamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name Acetohexamide CAS Number 968-81-0 Molecular Weight 324.39500 Density 1.3g/cm3 Boiling Point / Molecular Formula C15 H20 N2 O4 S Melting Point 188-190° (GB 912789); mp 175-177° (Marshall) MSDS ChineseUSA Flash Point /
Names Name acetohexamide Synonym More Synonyms
Acetohexamide BiologicalActivity Description Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin. Related Catalog Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
Chemical & Physical Properties Density 1.3g/cm3 Melting Point 188-190° (GB 912789); mp 175-177° (Marshall) Molecular Formula C15 H20 N2 O4 S Molecular Weight 324.39500 Exact Mass 324.11400 PSA 100.72000 LogP 4.07240 Appearance of Characters solid | white Index of Refraction 1.581 InChIKey VGZSUPCWNCWDAN-UHFFFAOYSA-N SMILES CC(=O)c1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1 Water Solubility DMSO: ~45 mg/mL
Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : YR7350000 CHEMICAL NAME : Urea, 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl- CAS REGISTRY NUMBER : 968-81-0 LAST UPDATED : 199806 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C15-H20-N2-O4-S MOLECULAR WEIGHT : 324.43 WISWESSER LINE NOTATION : L6TJ AMVMSWR DV1 HEALTH HAZARD DATAACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,34,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,18,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 900 mg/kg SEX/DURATION : female 26-39 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,187,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83998 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 627 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83998 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1626 (estimated) No. of Female Employees: 833 (estimated)
Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Safety Phrases S36 RIDADR NONH for all modes of transport WGK Germany 2 RTECS YR7350000 HS Code 2935009090
Customs HS Code 2935009090 Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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Detail CURRENT THERAPEUTICS. CCII. ACETOHEXAMIDE.Practitioner 193 , 555-60, (1964)
Detail
Synonyms Metaglucina Gamadiabet 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea MFCD00072156 acetoxehamide Acetohexamidum Hypoglicil Dimelin Acetohexamid N(2)-Cyclohexyl-N(1)-(4-acetylbenzenesulfonyl) Urea EINECS 213-530-4 N'-<4-Acetyl-benzolsulfonyl>-N-cyclohexyl-harnstoff N-(p-Acetyl-benzolsulfonyl)-N'-(cyclohexyl)-harnstoff Dymelor Dimelor Acetohexamida N-Cyclohexyl-N'-<4-acetyl-benzolsulfonyl>-harnstoff
