Introduction：Basic information about CAS 135911-02-3|RP 67580, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RP 67580 |
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| CAS Number | 135911-02-3 | Molecular Weight | 438.56 |
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| Density | 1.17 g/cm3 | Boiling Point | 588.5ºC at 760 mmHg |
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| Molecular Formula | C29H30N2O2 | Melting Point | 195-188ºC |
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| MSDS | / | Flash Point | 309.7ºC |
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Names
| Name | (3aR,7aR)-2-[2-(2-methoxyphenyl)ethanimidoyl]-7,7-diphenyl-1,3,3a,5,6,7a-hexahydroisoindol-4-one |
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| Synonym | More Synonyms |
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RP 67580 BiologicalActivity
| Description | RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor |
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| In Vivo | RP 67580（0.03-1 mg/kg；静脉注射；单剂量）显著抑制神经源性炎症。 Animal Model: Male albino Sprague-Dawley rats Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: i.v.; single dose Result: Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg. |
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| References | [1]. Garret C, et al. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12. |
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Chemical & Physical Properties
| Density | 1.17 g/cm3 |
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| Boiling Point | 588.5ºC at 760 mmHg |
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| Melting Point | 195-188ºC |
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| Molecular Formula | C29H30N2O2 |
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| Molecular Weight | 438.56 |
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| Flash Point | 309.7ºC |
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| Exact Mass | 438.23100 |
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| PSA | 53.39000 |
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| LogP | 5.14980 |
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| Vapour Pressure | 7.89E-14mmHg at 25°C |
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| Index of Refraction | 1.626 |
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| InChIKey | VWBOQFANCXZMAU-LOSJGSFVSA-N |
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| SMILES | COc1ccccc1CC(=N)N1CC2C(=O)CCC(c3ccccc3)(c3ccccc3)C2C1 |
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Synonyms
