Introduction：Basic information about CAS 64603-91-4|gaboxadol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | gaboxadol |
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| CAS Number | 64603-91-4 | Molecular Weight | 140.140 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 340.5±42.0 °C at 760 mmHg |
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| Molecular Formula | C6H9ClN2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 159.7±27.9 °C |
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Names
| Name | THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride |
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| Synonym | More Synonyms |
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gaboxadol BiologicalActivity
| Description | THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| Target | α4β3δ GABAAR:13 μM (EC50) |
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| References | [1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 340.5±42.0 °C at 760 mmHg |
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| Molecular Formula | C6H9ClN2O2 |
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| Molecular Weight | 140.140 |
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| Flash Point | 159.7±27.9 °C |
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| Exact Mass | 140.058578 |
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| PSA | 58.29000 |
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| LogP | -0.61 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.551 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NY3396800
- CHEMICAL NAME :
- Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate
- CAS REGISTRY NUMBER :
- 64603-91-4
- LAST UPDATED :
- 199103
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C6-H8-N2-O2.H2-O
- MOLECULAR WEIGHT :
- 158.18
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
- REFERENCE :
- NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982
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Synonyms
| Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro- |
| 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one |
| 4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridine-3-ol |
| 3-methoxy-4,5,6,7-tetrahydroisoxazole<5,4-c>pyridinium |
| Isoxazolo(4,5-d)pyridin-3(2H)-one, 4,5,6,7-tetrahydro- |
| 4,5,6,7-Tetrahydroisoxazolo<5,4-c>-pyridin-3-ol |
| THIP HYDROCHLORIDE |
| 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol |
| 4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one |
| Gaboxadolum |
| THPO |
| 4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate |
| Einecs 264-963-0 |
| Lu 02-030 |
| THIP |
| gaboxadol |
