CAS 134179-38-7|Amino-PEG3-C2-Azido
| Common Name | Amino-PEG3-C2-Azido | ||
|---|---|---|---|
| CAS Number | 134179-38-7 | Molecular Weight | 218.25400 |
| Density | 1.1 | Boiling Point | 198-202ºC |
| Molecular Formula | C8H18N4O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | 11-Azido-3,6,9-trioxaundecan-1-amine |
|---|---|
| Synonym | More Synonyms |
Amino-PEG3-C2-Azido BiologicalActivity
| Description | Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| In Vitro | Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1]. |
| References | [1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. |
Chemical & Physical Properties
| Density | 1.1 |
|---|---|
| Boiling Point | 198-202ºC |
| Molecular Formula | C8H18N4O3 |
| Molecular Weight | 218.25400 |
| Exact Mass | 218.13800 |
| PSA | 103.46000 |
| LogP | 0.45826 |
| Index of Refraction | 1.47 |
| InChIKey | FPVCVHVTMPCZTH-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCN |
| Storage condition | Amber Vial, Refrigerator, Under Inert Atmosphere |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C,Xi |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 2735 |
| WGK Germany | 3 |
| Packaging Group | III |
| HS Code | 2929909090 |
Customs
| HS Code | 2929909090 |
|---|---|
| Summary | 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles6
More Articles| Cytocompatible in situ forming chitosan/hyaluronan hydrogels via a metal-free click chemistry for soft tissue engineering. Acta Biomater. 20 , 60-8, (2015) Injectable hydrogels are important cell scaffolding materials for tissue engineering and regenerative medicine. Here, we report a new class of biocompatible and biodegradable polysaccharide hydrogels ... | |
| Microbial transglutaminase and c-myc-tag: a strong couple for the functionalization of antibody-like protein scaffolds from discovery platforms. ChemBioChem. 16(5) , 861-7, (2015) Antibody-like proteins selected from discovery platforms are preferentially functionalized by site-specific modification as this approach preserves the binding abilities and allows a side-by-side comp... | |
| Synthesis of "click" alginate hydrogel capsules and comparison of their stability, water swelling, and diffusion properties with that of Ca(+2) crosslinked alginate capsules. J. Biomed. Mater. Res. B. Appl. Biomater. 103 , 1120-32, (2015) Ionically crosslinked alginate hydrogels have been extensively explored for encapsulation and immunoisolation of living cells/tissues to develop implantable cell therapies, such as islet encapsulation... |
Synonyms
| Azido-PEG3-Amine |
| Amino-PEG3-Azide |
| 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine |
| 1-Amino-11-azido-3,6,9-trioxaundecane |
| 11-Amino-3,6,9-trioxaundecanyl Azide |
